Drug General Information
Drug ID
D08WDW
Former ID
DNC007826
Drug Name
DYSIDENIN
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529029]
Structure
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2D MOL

3D MOL

Formula
C17H23Cl6N3O2S
Canonical SMILES
CC(CC(C(=O)NC(C)C1=NC=CS1)N(C)C(=O)CC(C)C(Cl)(Cl)Cl)C(C<br />l)(Cl)Cl
InChI
1S/C17H23Cl6N3O2S/c1-9(16(18,19)20)7-12(14(28)25-11(3)15-24-5-6-29-15)26(4)13(27)8-10(2)17(21,22)23/h5-6,9-12H,7-8H2,1-4H3,(H,25,28)/t9-,10-,11-,12-/m0/s1
InChIKey
BFVRAKVNXYQMID-BJDJZHNGSA-N
PubChem Compound ID
Target and Pathway
Target(s) Arachidonate 15-lipoxygenase Target Info Inhibitor [529029]
Arachidonate 12-lipoxygenase, 12S-type Target Info Inhibitor [529029]
BioCyc Pathway Resolvin D biosynthesis
Lipoxin biosynthesisPWY66-392:Lipoxin biosynthesis
KEGG Pathway Arachidonic acid metabolism
Linoleic acid metabolism
Metabolic pathways
Serotonergic synapsehsa00590:Arachidonic acid metabolism
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Inflammation mediated by chemokine and cytokine signaling pathwayP00031:Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database IL4-mediated signaling events
PathWhiz Pathway Arachidonic Acid MetabolismPW000044:Arachidonic Acid Metabolism
WikiPathways Arachidonic acid metabolism
Eicosanoid SynthesisWP2650:Arachidonic acid metabolism
Eicosanoid Synthesis
References
Ref 529029Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.
Ref 529029Bioorg Med Chem. 2007 Nov 15;15(22):6900-8. Epub 2007 Aug 22.Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries.

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