Drug General Information
Drug ID	D0I5CT
Former ID	DIB018848
Drug Name	amthamine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540628]
Structure		Download 2D MOL
Formula	C6H11N3S
InChI	InChI=1S/C6H11N3S/c1-4-5(2-3-7)10-6(8)9-4/h2-3,7H2,1H3,(H2,8,9)
InChIKey	LHVRFUVVRXGZPV-UHFFFAOYSA-N
PubChem Compound ID	126688
PubChem Substance ID	7463560, 7978705, 10241626, 11113633, 14772393, 26751833, 29306178, 49846695, 53728491, 57341870, 85177274, 85208949, 85788610, 103245318, 104364188, 128491446, 132554051, 135083765, 137006440, 163124491, 164847658, 172912830, 174527483, 178100851, 184596032, 204380233, 226728866
Target and Pathway
Target(s)	Histamine H2 receptor	Target Info	Agonist	[529861]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gastric acid secretion
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Histamine H2 receptor mediated signaling pathway
PathWhiz Pathway	Intracellular Signalling Through Histamine H2 Receptor and Histamine
	Gastric Acid Production
Reactome	Histamine receptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Secretion of Hydrochloric Acid in Parietal Cells
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 540628	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4025).
Ref 529861	N(G)-acylated aminothiazolylpropylguanidines as potent and selective histamine H(2) receptor agonists. ChemMedChem. 2009 Feb;4(2):232-40.

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