Drug Information
Drug General Information | |||||
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Drug ID |
D09DHT
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Former ID |
DIB020710
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Drug Name |
phorbol 12-myristate 13-acetate
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Synonyms |
TPA; 12-O-tetradecanoylphorbol-13-acetate; tetradecanoyl-beta-phorbol acetate
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539485] | ||
Structure |
Download2D MOL |
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Formula |
C36H56O8
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InChI |
InChI=1S/C36H56O8/c1-7-8-9-10-11-12-13-14-15-16-17-18-29(39)43-32-24(3)35(42)27(30-33(5,6)36(30,32)44-25(4)38)20-26(22-37)21-34(41)28(35)19-23(2)31(34)40/h19-20,24,27-28,30,32,37,41-42H,7-18,21-22H2,1-6H3/t24-,27+,28-,30-,32-,34-,35-,36-/m1/s1
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InChIKey |
PHEDXBVPIONUQT-RGYGYFBISA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
7569, 139224, 492937, 596579, 3154907, 3288052, 7980341, 11120181, 11120669, 11121157, 11121697, 11122177, 11147264, 11342072, 11362255, 11362778, 11365340, 11367902, 11370807, 11370808, 11373503, 11374437, 11376064, 11404383, 11485638, 11487657, 11489727, 11492704, 14789656, 14838769, 17487166, 22391478, 24278653, 24887446, 24898219, 26613354, 26681074, 26681470, 26755285, 34670407, 46487935, 47290908, 47736218, 47885175, 48034851, 50110884, 53790708, 57244624, 57310548, 57652787
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Target and Pathway | |||||
Target(s) | KNa1.2 | Target Info | Inhibitor (gating inhibitor) | [528200] | |
Transient receptor potential cation channel subfamily V member 4 | Target Info | Activator | [526264] | ||
KNa1.1 | Target Info | Activator | [528200] | ||
ATP-sensitive K+ channel | Target Info | Inhibitor (gating inhibitor) | [526933] | ||
PathWhiz Pathway | Muscle/Heart Contraction | ||||
References | |||||
Ref 526264 | Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem. 2002 Apr 19;277(16):13569-77. Epub 2002 Feb 4. | ||||
Ref 526933 | Molecular basis for the inhibition of G protein-coupled inward rectifier K(+) channels by protein kinase C. Proc Natl Acad Sci U S A. 2004 Jan 27;101(4):1087-92. Epub 2004 Jan 19. | ||||
Ref 528200 | Opposite regulation of Slick and Slack K+ channels by neuromodulators. J Neurosci. 2006 May 10;26(19):5059-68. |
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