Drug Information

Drug General Information
Drug ID
D0G8FT
Former ID
DIB020365
Drug Name
ML204
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467590]
Structure
Download
2D MOL
Formula
C15H18N2
InChI
InChI=1S/C15H18N2/c1-12-11-15(17-9-5-2-6-10-17)16-14-8-4-3-7-13(12)14/h3-4,7-8,11H,2,5-6,9-10H2,1H3
InChIKey
USYRQXDHKXGTCK-UHFFFAOYSA-N
PubChem Compound ID
230710
PubChem Substance ID
86895, 3356884, 5621460, 9383217, 15763606, 24829278, 30030343, 50630616, 87713812, 97362164, 103140185, 104445559, 105585362, 117520929, 118407930, 125111603, 126463383, 130671417, 135568260, 142020966, 143964295, 162870448, 164058536, 168303981, 172892255, 178101072, 179215026, 239940260, 242263679, 244773323, 248873830, 252141322, 252158309, 252271935, 252450214, 252552001, 252654648
Target and Pathway
Target(s) TRPC4 Target Info Blocker (channel blocker) [531580]
TRP cation channel C5 Target Info Blocker (channel blocker) [531580]
PANTHER Pathway Alzheimer disease-presenilin pathway
Reactome TRP channels
Role of second messengers in netrin-1 signaling
WikiPathways Netrin-1 signaling
References
Ref 467590(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4255).
Ref 531580Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels. J Biol Chem. 2011 Sep 23;286(38):33436-46.

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