TTD | Drug: D0ZG7W

Drug General Information
Drug ID	D0ZG7W
Former ID	DIB018732
Drug Name	Abbott 14c
Synonyms	2,4-diaminopyrimidine-based antagonist, 14c
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541180]
Structure		Download 2D MOL
Formula	C23H28N6O2
InChI	InChI=1S/C23H28N6O2/c1-23(2,3)29-22(30)26-17-11-9-16(10-12-17)19-18(27-21(25)28-20(19)24)14-31-13-15-7-5-4-6-8-15/h4-12H,13-14H2,1-3H3,(H2,26,29,30)(H4,24,25,27,28)
InChIKey	MLBYOWASRACYDH-UHFFFAOYSA-N
PubChem Compound ID	11441554
PubChem Substance ID	16539810, 23584076, 42520591, 46519394, 77428637, 103493332, 178102495, 232129723, 248574329
Target and Pathway
Target(s)	Growth hormone secretagogue receptor type 1	Target Info	Antagonist	[528319]
KEGG Pathway	cAMP signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	Leptin Signaling Pathway
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541180	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5871).
Ref 528319	Discovery and pharmacological evaluation of growth hormone secretagogue receptor antagonists. J Med Chem. 2006 Jul 27;49(15):4459-69.

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Drug Information