Drug Information

Drug General Information
Drug ID
D0K1MA
Former ID
DNC003504
Drug Name
CGS-314447
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551340]
Structure
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2D MOL

3D MOL
Formula
C27H26N5O3P
Canonical SMILES
C1=CC=C(C=C1)C2=CC=C(C=C2)CC(C3=NNN=N3)NC(CC4=CC5=CC=CC<br />=C5C=C4)P(=O)(O)O
InChI
1S/C27H26N5O3P/c33-36(34,35)26(18-20-12-15-22-8-4-5-9-24(22)16-20)28-25(27-29-31-32-30-27)17-19-10-13-23(14-11-19)21-6-2-1-3-7-21/h1-16,25-26,28H,17-18H2,(H2,33,34,35)(H,29,30,31,32)/t25-,26?/m0/s1
InChIKey
PIBUIEXHVFJHNQ-PMCHYTPCSA-N
PubChem Compound ID
9913857
Target and Pathway
Target(s) Neutral endopeptidase Target Info Inhibitor [551340]
KEGG Pathway Renin-angiotensin system
Hematopoietic cell lineage
Protein digestion and absorption
Alzheimer's disease
NetPath Pathway EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Reactome Metabolism of Angiotensinogen to Angiotensins
WikiPathways Metabolism of Angiotensinogen to Angiotensins
Primary Focal Segmental Glomerulosclerosis FSGS
Alzheimers Disease
References
Ref 551340Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11, Bioorg. Med. Chem. Lett. 7(8):1059-1064 (1997).
Ref 551340Potent non-peptidic dual inhibitors of endothelin-converting enzyme and neutral endopeptidase 24.11, Bioorg. Med. Chem. Lett. 7(8):1059-1064 (1997).

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