Drug Information

Drug General Information
Drug ID
D0A5RM
Former ID
DNC006929
Drug Name
4-[(3,5-diamino-1H-pyrazol-4-yl)diazenyl]phenol
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528490]
Structure
Download
2D MOL

3D MOL
Formula
C9H10N6O
Canonical SMILES
C1=CC(=O)C=CC1=NNC2=C(NN=C2N)N
InChI
1S/C9H10N6O/c10-8-7(9(11)15-14-8)13-12-5-1-3-6(16)4-2-5/h1-4,13H,(H5,10,11,14,15)
InChIKey
FHZNRKGCGRGLFC-UHFFFAOYSA-N
PubChem Compound ID
9859248
Target and Pathway
Target(s) Cell division protein kinase 2 Target Info Inhibitor [528490]
Cyclin-A2 Target Info Inhibitor [528490]
Mitogen-activated protein kinase 1 Target Info Inhibitor [528490]
Casein kinase II, alpha chain Target Info Inhibitor [528490]
Protein kinase A Target Info Inhibitor [528490]
CAMP-dependent protein kinase type II-beta regulatory chain Target Info Inhibitor [528490]
Cell division protein kinase 9 Target Info Inhibitor [528490]
Serine/threonine-protein kinase Chk1 Target Info Inhibitor [528490]
Ribosomal protein S6 kinase Target Info Inhibitor [528490]
G1/S-specific cyclin D1 Target Info Inhibitor [528490]
G1/S-specific cyclin E1 Target Info Inhibitor [528490]
mRNA of PKA Catalytic Subunit C-alpha Target Info Inhibitor [528490]
Glycogen synthase kinase-3 beta Target Info Inhibitor [528490]
Proto-oncogene c-Abl Target Info Inhibitor [528490]
Mitogen-activated protein kinase 14 Target Info Inhibitor [528490]
RAC serine/threonine-protein kinase Target Info Inhibitor [528490]
Cell division protein kinase 4 Target Info Inhibitor [528490]
KEGG Pathway FoxO signaling pathway
Cell cycle
Oocyte meiosis
p53 signaling pathway
PI3K-Akt signaling pathway
Progesterone-mediated oocyte maturation
Hepatitis B
Measles
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Prostate cancer
Small cell lung cancerhsa03030:DNA replication
Base excision repair
Nucleotide excision repair
Mismatch repair
HTLV-I infectionhsa04010:MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
Sphingolipid signaling pathway
mTOR signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Shigellosis
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Influenza A
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancerhsa03008:Ribosome biogenesis in eukaryotes
NF-kappa B signaling pathway
Wnt signaling pathway
Tight junction
Epstein-Barr virus infectionhsa04210:Apoptosis
Insulin signaling pathwayhsa05202:Transcriptional misregulation in cancerhsa04110:Cell cycle
HTLV-I infection
Viral carcinogenesishsa04012:ErbB signaling pathway
AMPK signaling pathway
Choline metabolism in cancerhsa04068:FoxO signaling pathway
Hippo signaling pathway
Jak-STAT signaling pathway
Small cell lung cancer
Viral myocarditishsa04110:Cell cycle
Small cell lung cancerhsa04010:MAPK signaling pathway
Calcium signaling pathway
Apoptosis
Hedgehog signaling pathway
GABAergic synapse
Dopaminergic synapse
Olfactory transduction
Taste transduction
Inflammatory mediator regulation of TRP channels
Insulin secretion
Ovarian steroidogenesis
Thyroid hormone synthesis
Glucagon signaling pathway
Regulation of lipolysis in adipocytes
Renin secretion
Endocrine and other factor-regulated calcium reabsorption
Vasopressin-regulated water reabsorption
Salivary secretion
Gastric acid secretion
Bile secretion
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Morphine addiction
Vibrio cholerae infection
Amoebiasis
Dilated cardiomyopathyhsa04012:ErbB signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Basal cell carcinomahsa04012:ErbB signaling pathway
Pathogenic Escherichia coli infection
Viral myocarditishsa04010:MAPK signaling pathway
RIG-I-like receptor signaling pathway
Leukocyte transendothelial migration
Amyotrophic lateral sclerosis (ALS)
Epithelial cell signaling in Helicobacter pylori infection
Proteoglycans in cancerhsa04010:MAPK signaling pathway
Adipocytokine signaling pathway
Carbohydrate digestion and absorption
Choline metabolism in cancerhsa04110:Cell cycle
NetPath Pathway TCR Signaling PathwayNetPath_14:IL2 Signaling PathwayNetPath_25:FSH Signaling PathwayNetPath_4:EGFR1 Signaling PathwayNetPath_11:TCR Signaling Pathway
IL2 Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
Notch Signaling Pathway
Wnt Signaling PathwayNetPath_14:IL2 Signaling Pathway
TCR Signaling PathwayNetPath_17:IL5 Signaling Pathway
FSH Signaling Pathway
TCR Signaling PathwayNetPath_23:TSH Signaling PathwayNetPath_11:TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway p53 pathway
p53 pathway feedback loops 2P00003:Alzheimer disease-amyloid secretase pathway
Angiogenesis
Apoptosis signaling pathway
B cell activation
EGF receptor signaling pathway
Endothelin signaling pathway
FGF signaling pathway
Inflammation mediated by chemokine and cytokine signaling pathway
Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Interferon-gamma signaling pathway
Interleukin signaling pathway
PDGF signaling pathway
Parkinson disease
TGF-beta signaling pathway
T cell activation
VEGF signaling pathway
Ras Pathway
Angiotensin II-stimulated signaling through G proteins and beta-arrestin
CCKR signaling map STP00019:Endothelin signaling pathway
Hedgehog signaling pathway
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group II pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Transcription regulation by bZIP transcription factor
5HT1 type receptor mediated signaling pathway
Beta1 adrenergic receptor signaling pathway
Beta2 adrenergic receptor signaling pathway
Histamine H2 receptor mediated signaling pathway
GABA-B receptor II signaling
Dopamine receptor mediated signaling pathway
Enkephalin releaseP00032:Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
PI3 kinase pathway
p53 pathway by glucose deprivation
CCKR signaling map STP00048:PI3 kinase pathway
Wnt signaling pathway
CCKR signaling map STP00013:Cell cycle
p53 pathway feedback loops 2P00019:Endothelin signaling pathway
Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction
Metabotropic glutamate receptor group I pathway
Enkephalin release
Nicotine pharmacodynamics pathway
CCKR signaling map STP00004:Alzheimer disease-presenilin pathway
Cadherin signaling pathway
Insulin/IGF pathway-protein kinase B signaling cascade
CCKR signaling map STP00008:Axon guidance mediated by Slit/RoboP00003:Alzheimer disease-amyloid secretase pathway
Oxidative stress response
Toll receptor signaling pathway
p53 pathway feedback loops 2
p38 MAPK pathway
CCKR signaling map STP00005:Angiogenesis
Huntington disease
Hypoxia response via HIF activation
CCKR signaling map ST
Pathway Interaction Database Regulation of nuclear SMAD2/3 signaling
Signaling events mediated by PRL
p73 transcription factor network
E2F transcription factor network
ATR signaling pathway
mTOR signaling pathway
IL2-mediated signaling events
FoxO family signaling
FOXM1 transcription factor network
BARD1 signaling events
p53 pathway
Regulation of retinoblastoma proteinfcer1pathway:Fc-epsilon receptor I signaling in mast cells
Endothelins
BCR signaling pathway
ErbB4 signaling events
GMCSF-mediated signaling events
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
S1P3 pathway
EPHB forward signaling
Osteopontin-mediated events
S1P4 pathway
Presenilin action in Notch and Wnt signaling
TRAIL signaling pathway
CDC42 signaling events
Signaling events regulated by Ret tyrosine kinase
Angiopoietin receptor Tie2-mediated signaling
S1P1 pathway
Regulation of Telomerase
Netrin-mediated signaling events
Glucocorticoid receptor regulatory network
Arf6 downstream pathway
Class IB PI3K non-lipid kinase events
EGF receptor (ErbB1) signaling pathway
Ras signaling in the CD4+ TCR pathway
Ceramide signaling pathway
Integrins in angiogenesis
IFN-gamma pathway
ErbB1 downstream signaling
ATF-2 transcription factor network
ErbB2/ErbB3 signaling events
BMP receptor signaling
ALK1 signaling events
PDGFR-beta signaling pathway
Neurotrophic factor-mediated Trk receptor signaling
Syndecan-1-mediated signaling events
Retinoic acid receptors-mediated signaling
Nongenotropic Androgen signaling
CXCR3-mediated signaling events
VEGFR1 specific signals
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
Signaling events mediated by VEGFR1 and VEGFR2
Syndecan-2-mediated signaling events
Cellular roles of Anthrax toxin
S1P2 pathway
Trk receptor signaling mediated by the MAPK pathway
Downstream signaling in na&#xef
VEGFR3 signaling in lymphatic endothelium
Alpha-synuclein signaling
FGF signaling pathway
Signaling events mediated by focal adhesion kinasebcr_5pathway:BCR signaling pathway
Atypical NF-kappaB pathway
DNA-PK pathway in nonhomologous end joining
Role of Calcineurin-dependent NFAT signaling in lymphocytes
E-cadherin signaling in the nascent adherens junction
Lissencephaly gene (LIS1) in neuronal migration and development
PDGFR-alpha signaling pathway
Signaling mediated by p38-alpha and p38-beta
Alpha-synuclein signalingfanconi_pathway:Fanconi anemia pathway
Circadian rhythm pathway
p53 pathwayinsulin_pathway:Insulin Pathway
IL4-mediated signaling events
IGF1 pathway
IL2 signaling events mediated by PI3K
RXR and RAR heterodimerization with other nuclear receptor
Signaling events mediated by Stem cell factor receptor (c-Kit)
a6b1 and a6b4 Integrin signaling
TGF-beta receptor signalingnotch_pathway:Notch signaling pathway
Coregulation of Androgen receptor activity
Validated transcriptional targets of AP1 family members Fra1 and Fra2
Integrin-linked kinase signaling
AP-1 transcription factor network
C-MYB transcription factor network
Validated nuclear estrogen receptor alpha network
Signaling mediated by p38-gamma and p38-delta
Regulation of nuclear beta catenin signaling and target gene transcription
Validated targets of C-MYC transcriptional repression
Trk receptor signaling mediated by PI3K and PLC-gamma
Regulation of retinoblastoma protein
Signaling events mediated by focal adhesion kinaseprlsignalingeventspathway:Signaling events mediated by PRL
PLK3 signaling events
Regulation of retinoblastoma proteingmcsf_pathway:GMCSF-mediated signaling events
LPA4-mediated signaling events
LKB1 signaling events
Thromboxane A2 receptor signaling
SHP2 signaling
Signaling events mediated by HDAC Class I
IL3-mediated signaling events
Hedgehog signaling events mediated by Gli proteins
Calcium signaling in the CD4+ TCR pathway
Aurora A signaling
Class I PI3K signaling events mediated by Akt
Alpha4 beta1 integrin signaling eventslysophospholipid_pathway:LPA receptor mediated events
Degradation of beta catenin
Reelin signaling pathway
Canonical Wnt signaling pathway
C-MYC pathway
Regulation of Androgen receptor activity
Validated transcriptional targets of deltaNp63 isoforms
Insulin-mediated glucose transport
Trk receptor signaling mediated by PI3K and PLC-gammap73pathway:p73 transcription factor network
ATM pathway
Posttranslational regulation of adherens junction stability and dissassembly
Validated transcriptional targets of TAp63 isoforms
Regulation of retinoblastoma proteinendothelinpathway:Endothelins
p38 MAPK signaling pathway
CD40/CD40L signaling
IL12-mediated signaling events
Regulation of p38-alpha and p38-beta
FAS (CD95) signaling pathway
Rapid glucocorticoid signaling
IL6-mediated signaling events
p38 signaling mediated by MAPKAP kinases
EPO signaling pathway
RAC1 signaling pathway
Regulation of retinoblastoma proteinsmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Fc-epsilon receptor I signaling in mast cells
LPA receptor mediated events
Insulin Pathway
TCR signaling in na&#xef
Plasma membrane estrogen receptor signaling
Signaling events mediated by PTP1B
TCR signaling in na&#xef
FOXA2 and FOXA3 transcription factor networks
CXCR4-mediated signaling events
p75(NTR)-mediated signaling
amb2 Integrin signaling
E-cadherin signaling in keratinocytes
Nephrin/Neph1 signaling in the kidney podocyte
IL8- and CXCR2-mediated signaling events
Signaling events mediated by the Hedgehog family
Caspase Cascade in Apoptosis
IL8- and CXCR1-mediated signaling events
HIF-1-alpha transcription factor network
FGF signaling pathwaysmad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Validated targets of C-MYC transcriptional activation
PathWhiz Pathway Nucleotide Excision RepairPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Fc Epsilon Receptor I Signaling in Mast Cells
Insulin SignallingPW000659:Leucine Stimulation on Insulin SignalingPW000564:Muscle/Heart ContractionPW000453:Fc Epsilon Receptor I Signaling in Mast CellsPW000445:Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome G0 and Early G1
Activation of ATR in response to replication stress
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Processing of DNA double-strand break ends
G2 Phase
Orc1 removal from chromatin
Cyclin E associated events during G1/S transition
Cyclin A/B1 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Meiotic recombination
Factors involved in megakaryocyte development and platelet productionR-HSA-113510:E2F mediated regulation of DNA replication
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
HDR through Homologous Recombination (HRR)
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
G1/S-Specific Transcription
Cyclin A:Cdk2-associated events at S phase entryR-HSA-112409:RAF-independent MAPK1/3 activation
MAPK1 (ERK2) activation
Golgi Cisternae Pericentriolar Stack Reorganization
ERK/MAPK targets
Regulation of actin dynamics for phagocytic cup formation
Oxidative Stress Induced Senescence
Oncogene Induced Senescence
FCERI mediated MAPK activation
Regulation of HSF1-mediated heat shock response
NCAM signaling for neurite out-growth
Recycling pathway of L1
CREB phosphorylation through the activation of Ras
Activation of the AP-1 family of transcription factors
Thrombin signalling through proteinase activated receptors (PARs)
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
RHO GTPases Activate WASPs and WAVEs
RAF/MAP kinase cascade
MAP2K and MAPK activation
Negative feedback regulation of MAPK pathway
Negative regulation of MAPK pathway
Signal attenuation
Advanced glycosylation endproduct receptor signaling
Gastrin-CREB signalling pathway via PKC and MAPK
Growth hormone receptor signalingR-HSA-2514853:Condensation of Prometaphase ChromosomesR-HSA-163615:PKA activation
PKA activation in glucagon signalling
DARPP-32 events
Regulation of PLK1 Activity at G2/M Transition
Loss of Nlp from mitotic centrosomes
Recruitment of mitotic centrosome proteins and complexes
Loss of proteins required for interphase microtubule organization?from the centrosome
Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
Vasopressin regulates renal water homeostasis via Aquaporins
Hedgehog 'off' state
Anchoring of the basal body to the plasma membrane
Factors involved in megakaryocyte development and platelet productionR-HSA-2173796:SMAD2/SMAD3:SMAD4 heterotrimer regulates transcriptionR-HSA-176187:Activation of ATR in response to replication stress
Presynaptic phase of homologous DNA pairing and strand exchange
G2/M DNA damage checkpoint
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-166208:mTORC1-mediated signallingR-HSA-1912408:Pre-NOTCH Transcription and Translation
RMTs methylate histone arginines
Ubiquitin-dependent degradation of Cyclin D1
Cyclin D associated events in G1R-HSA-113510:E2F mediated regulation of DNA replication
p53-Dependent G1 DNA Damage ResponseR-HSA-163560:Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
PKA activation
Regulation of insulin secretion
VEGFA-VEGFR2 Pathway
Interleukin-3, 5 and GM-CSF signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
CD209 (DC-SIGN) signaling
MAPK6/MAPK4 signaling
Gluconeogenesis
Factors involved in megakaryocyte development and platelet productionR-HSA-195253:Degradation of beta-catenin by the destruction complex
AKT phosphorylates targets in the cytosol
CRMPs in Sema3A signaling
Disassembly of the destruction complex and recruitment of AXIN to the membrane
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
Constitutive Signaling by AKT1 E17K in CancerR-HSA-2029482:Regulation of actin dynamics for phagocytic cup formation
CDO in myogenesis
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Factors involved in megakaryocyte development and platelet productionR-HSA-168638:NOD1/2 Signaling Pathway
p38MAPK events
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
DSCAM interactions
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
activated TAK1 mediates p38 MAPK activation
KSRP (KHSRP) binds and destabilizes mRNAR-HSA-111447:Activation of BAD and translocation to mitochondria
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Translocation of GLUT4 to the plasma membrane
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
AKT phosphorylates targets in the nucleus
Negative regulation of the PI3K/AKT network
eNOS activation
AKT-mediated inactivation of FOXO1A
Integrin alphaIIb beta3 signaling
Deactivation of the beta-catenin transactivating complex
CD28 dependent PI3K/Akt signaling
CTLA4 inhibitory signaling
G beta:gamma signalling through PI3Kgamma
KSRP (KHSRP) binds and destabilizes mRNA
VEGFR2 mediated vascular permeability
TP53 Regulates Metabolic Genes
Constitutive Signaling by AKT1 E17K in CancerR-HSA-2559580:Oxidative Stress Induced Senescence
Transcriptional regulation of white adipocyte differentiation
Cyclin D associated events in G1
WikiPathways DNA Damage Response
ID signaling pathway
DNA Replication
G1 to S cell cycle control
M/G1 Transition
S Phase
Meiotic Recombination
Aryl Hydrocarbon Receptor
ATM Signaling Pathway
Retinoblastoma (RB) in Cancer
Spinal Cord Injury
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Prostate Cancer
Signaling Pathways in Glioblastoma
TSH signaling pathway
Integrated Breast Cancer Pathway
Integrated Cancer pathway
Synthesis of DNA
Regulation of DNA replication
Mitotic G2-G2/M phases
Mitotic G1-G1/S phases
Factors involved in megakaryocyte development and platelet production
Cell Cycle
APC/C-mediated degradation of cell cycle proteins
Cell Cycle Checkpoints
miRNA Regulation of DNA Damage ResponseWP615:Senescence and Autophagy in Cancer
Mismatch repair
EGF/EGFR Signaling Pathway
Nifedipine Activity
Primary Focal Segmental Glomerulosclerosis FSGS
Nucleotide Excision Repair
Telomere Maintenance
Base Excision RepairWP75:Toll-like receptor signaling pathway
Serotonin Receptor 4/6/7 and NR3C Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Serotonin HTR1 Group and FOS Pathway
Vitamin A and Carotenoid Metabolism
DNA Damage Response (only ATM dependent)
TCR Signaling Pathway
ErbB Signaling Pathway
Hypothetical Network for Drug Addiction
Senescence and Autophagy in Cancer
EPO Receptor Signaling
Regulation of Actin Cytoskeleton
IL-2 Signaling Pathway
Insulin Signaling
MAPK Cascade
IL-4 Signaling Pathway
MAPK Signaling Pathway
TGF beta Signaling Pathway
IL-6 signaling pathway
Signaling of Hepatocyte Growth Factor Receptor
Kit receptor signaling pathway
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
Apoptosis-related network due to altered Notch3 in ovarian cancer
IL-3 Signaling Pathway
Bladder Cancer
Cardiac Hypertrophic Response
MAP kinase activation in TLR cascade
Fc epsilon receptor (FCERI) signaling
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
RAF/MAP kinase cascade
Nanoparticle-mediated activation of receptor signaling
Structural Pathway of Interleukin 1 (IL-1)
Genes and (Common) Pathways Underlying Drug Addiction
EBV LMP1 signaling
Signal Transduction of S1P Receptor
PDGF Pathway
Alpha 6 Beta 4 signaling pathway
BDNF signaling pathway
Corticotropin-releasing hormone
Interleukin-11 Signaling Pathway
AGE/RAGE pathway
TNF alpha Signaling Pathway
B Cell Receptor Signaling Pathway
TSLP Signaling Pathway
IL-9 Signaling Pathway
Endothelin Pathways
IL17 signaling pathway
Alzheimers Disease
IL-7 Signaling Pathway
TWEAK Signaling Pathway
FSH signaling pathway
Leptin signaling pathway
RANKL/RANK Signaling Pathway
Opioid Signalling
IL-1 signaling pathway
Thrombin signalling through proteinase activated receptors (PARs)
Signaling by FGFR
Integrin-mediated Cell Adhesion
L1CAM interactions
Advanced glycosylation endproduct receptor signaling
Heart Development
Type II diabetes mellitus
MicroRNAs in cardiomyocyte hypertrophy
Angiogenesis
Physiological and Pathological Hypertrophy of the Heart
Regulation of toll-like receptor signaling pathway
Osteopontin Signaling
IL-5 Signaling PathwayWP2652:Mitotic Prometaphase
L1CAM interactionsWP706:SIDS Susceptibility Pathways
Calcium Regulation in the Cardiac Cell
G Protein Signaling Pathways
Myometrial Relaxation and Contraction Pathways
DAG and IP3 signaling
Regulation of Water Balance by Renal Aquaporins
miRs in Muscle Cell Differentiation
Integration of energy metabolism
Factors involved in megakaryocyte development and platelet productionWP2795:Cardiac Hypertrophic Response
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Host Interactions of HIV factors
HIV Life Cycle
RNA Polymerase II Transcription
MicroRNAs in cardiomyocyte hypertrophyWP707:DNA Damage Response
Signaling by SCF-KIT
miRNA Regulation of DNA Damage ResponseWP673:ErbB Signaling Pathway
Interferon type I signaling pathways
G13 Signaling Pathway
Cytoplasmic Ribosomal Proteins
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
Signaling by Insulin receptor
TOR Signaling
AMPK Signaling
IL-5 Signaling PathwayWP710:DNA Damage Response (only ATM dependent)
Notch Signaling Pathway
Wnt Signaling Pathway and Pluripotency
Wnt Signaling Pathway Netpath
Copper homeostasis
Focal Adhesion
PPAR Alpha Pathway
Mesodermal Commitment Pathway
Hair Follicle Development: Organogenesis (Part 2 of 3)
Pre-NOTCH Expression and Processing
Polycystic Kidney Disease Pathway
miR-targeted genes in muscle cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in epithelium - TarBase
miRNAs involved in DNA damage response
miRNA Regulation of DNA Damage Response
Androgen receptor signaling pathwayWP707:DNA Damage Response
Parkinsons Disease Pathway
Parkin-Ubiquitin Proteasomal System pathway
Androgen receptor signaling pathwayWP706:SIDS Susceptibility Pathways
Endochondral Ossification
Human Complement System
Dopamine metabolism
Regulation of Microtubule Cytoskeleton
SREBP signalling
Nicotine Activity on Dopaminergic NeuronsWP710:DNA Damage Response (only ATM dependent)
Glycogen Metabolism
Wnt Signaling Pathway
Hair Follicle Development: Induction (Part 1 of 3)
Degradation of beta-catenin by the destruction complex
T-Cell Receptor and Co-stimulatory Signaling
Cardiac Progenitor Differentiation
Neural Crest Differentiation
Semaphorin interactions
Androgen receptor signaling pathway
IL-5 Signaling PathwayWP2864:Apoptosis-related network due to altered Notch3 in ovarian cancer
Fcgamma receptor (FCGR) dependent phagocytosis
Pathogenic Escherichia coli infection
Signaling by Robo receptor
Myogenesis
Factors involved in megakaryocyte development and platelet productionWP75:Toll-like receptor signaling pathway
Monoamine Transport
Oxidative Stress
p38 MAPK Signaling Pathway
Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
JAK/STAT
Amyotrophic lateral sclerosis (ALS)
miR-targeted genes in leukocytes - TarBase
Signal amplification
Platelet homeostasis
NGF signalling via TRKA from the plasma membrane
DSCAM interactions
Regulation of toll-like receptor signaling pathwayWP75:Toll-like receptor signaling pathway
Extracellular vesicle-mediated signaling in recipient cells
Translocation of GLUT4 to the Plasma Membrane
PIP3 activates AKT signaling
Apoptosis
Metabolism of nitric oxide
TFs Regulate miRNAs related to cardiac hypertrophy
IL-5 Signaling PathwayWP707:DNA Damage Response
Ovarian Infertility Genes
Transcriptional Regulation of White Adipocyte Differentiation
References
Ref 528490J Med Chem. 2006 Nov 2;49(22):6500-9.4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.
Ref 528490J Med Chem. 2006 Nov 2;49(22):6500-9.4-arylazo-3,5-diamino-1H-pyrazole CDK inhibitors: SAR study, crystal structure in complex with CDK2, selectivity, and cellular effects.

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