| Drug General Information |
| Drug ID |
D0R4BS
|
| Former ID |
DNC005413
|
| Drug Name |
N-Hydroxy-4-(3-phenyl-propionylamino)-benzamide
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| Synonyms |
N-hydroxy-4-(3-phenylpropanamido)benzamide
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| Indication |
Discovery agent
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Investigative |
[1]
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| Structure |
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Download
2D MOL
3D MOL
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| Target and Pathway |
| Target(s) |
Histone deacetylase 2 |
Target Info |
Inhibitor |
[2]
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| Histone Deacetylase 10 |
Target Info |
Inhibitor |
[1]
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| Histone Deacetylase 8 |
Target Info |
Inhibitor |
[1]
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| Histone deacetylase 1 |
Target Info |
Inhibitor |
[2]
|
| Histone deacetylase 6 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase 4 |
Target Info |
Inhibitor |
[1]
|
| Histone deacetylase |
Target Info |
Inhibitor |
[1]
|
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KEGG Pathway
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Cell cycle
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Notch signaling pathway
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Thyroid hormone signaling pathway
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Huntington's disease
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Alcoholism
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Epstein-Barr virus infection
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Pathways in cancer
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Transcriptional misregulation in cancer
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Viral carcinogenesis
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Chronic myeloid leukemiahsa05034:Alcoholism
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Viral carcinogenesishsa04110:Cell cycle
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Amphetamine addiction
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MicroRNAs in cancer
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Viral carcinogenesishsa05034:Alcoholism
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NetPath Pathway
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TCR Signaling PathwayNetPath_11:TCR Signaling PathwayNetPath_14:IL2 Signaling Pathway
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PANTHER Pathway
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Wnt signaling pathwayP00057:Wnt signaling pathwayP00057:Wnt signaling pathway
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p53 pathway
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Pathway Interaction Database
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Regulation of nuclear SMAD2/3 signaling
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Signaling events mediated by HDAC Class I
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Regulation of Telomerase
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Glucocorticoid receptor regulatory network
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Direct p53 effectors
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Hedgehog signaling events mediated by Gli proteins
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Regulation of nuclear beta catenin signaling and target gene transcriptionhdac_classii_pathway:Signaling events mediated by HDAC Class II
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Signaling events mediated by HDAC Class Ihdac_classi_pathway:Signaling events mediated by HDAC Class Ismad2_3nuclearpathway:Regulation of nuclear SMAD2/3 signaling
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Notch signaling pathway
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E2F transcription factor network
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Presenilin action in Notch and Wnt signaling
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Sumoylation by RanBP2 regulates transcriptional repression
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Regulation of Androgen receptor activity
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IL3-mediated signaling events
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Validated nuclear estrogen receptor alpha network
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Retinoic acid receptors-mediated signaling
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Regulation of nuclear beta catenin signaling and target gene transcription
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Validated targets of C-MYC transcriptional repression
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Regulation of retinoblastoma protein
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Notch-mediated HES/HEY networkhdac_classii_pathway:Signaling events mediated by HDAC Class II
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Signaling events mediated by HDAC Class Ihdac_classii_pathway:Signaling events mediated by HDAC Class II
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Signaling events mediated by HDAC Class III
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Reactome
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p75NTR negatively regulates cell cycle via SC1
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NOTCH1 Intracellular Domain Regulates Transcription
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Constitutive Signaling by NOTCH1 PEST Domain Mutants
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Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
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HDACs deacetylate histones
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NoRC negatively regulates rRNA expression
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RNA Polymerase I Transcription Initiation
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Factors involved in megakaryocyte development and platelet productionR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
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HDACs deacetylate histonesR-HSA-1538133:G0 and Early G1
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Formation of the beta-catenin:TCF transactivating complex
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SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
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Deactivation of the beta-catenin transactivating complex
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Assembly of the primary ciliumR-HSA-2122947:NOTCH1 Intracellular Domain Regulates Transcription
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WikiPathways
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Notch Signaling Pathway
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Notch Signaling Pathway
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Neural Crest Differentiation
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Signalling by NGF
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RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription
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Factors involved in megakaryocyte development and platelet production
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Cell CycleWP2377:Integrated Pancreatic Cancer Pathway
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Cell CycleWP706:SIDS Susceptibility Pathways
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TGF beta Signaling Pathway
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IL-6 signaling pathway
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Apoptosis-related network due to altered Notch3 in ovarian cancer
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Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
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Retinoblastoma (RB) in Cancer
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TWEAK Signaling Pathway
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Integrated Breast Cancer Pathway
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Mitotic G1-G1/S phases
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Cell Cycle
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Androgen receptor signaling pathwayWP2858:Ectoderm Differentiation
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Cell CycleWP474:Endochondral Ossification
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Cardiac Hypertrophic Response
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miR-targeted genes in muscle cell - TarBase
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miR-targeted genes in lymphocytes - TarBase
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miR-targeted genes in epithelium - TarBase
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TarBasePathway
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MicroRNAs in cardiomyocyte hypertrophy
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| References |
| REF 1 | J Med Chem. 2005 Aug 25;48(17):5530-5.Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors. |
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| REF 2 | Eur J Med Chem. 2009 Nov;44(11):4470-6. Epub 2009 Jun 17.Design, synthesis and preliminary biological evaluation of N-hydroxy-4-(3-phenylpropanamido)benzamide (HPPB) derivatives as novel histone deacetylase inhibitors. |
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