Drug Information

Drug General Information
Drug ID
D09YVN
Former ID
DNC003183
Drug Name
Dihydrofolic Acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL

3D MOL
Formula
C19H21N7O6
Canonical SMILES
C1C(=NC2=C(N1)NC(=NC2=O)N)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O<br />)O)C(=O)O
InChI
1S/C19H21N7O6/c20-19-25-15-14(17(30)26-19)23-11(8-22-15)7-21-10-3-1-9(2-4-10)16(29)24-12(18(31)32)5-6-13(27)28/h1-4,12,21H,5-8H2,(H,24,29)(H,27,28)(H,31,32)(H4,20,22,25,26,30)/t12-/m0/s1
InChIKey
OZRNSSUDZOLUSN-LBPRGKRZSA-N
CAS Number
CAS 4033-27-6
PubChem Compound ID
98792
PubChem Substance ID
3705, 219467, 7887020, 8143289, 10230047, 15007999, 15201936, 26707966, 44429037, 47349646, 50100134, 53787799, 57336759, 75381546, 103232782, 103918104, 104423382, 126523774, 128884694, 135055769, 137156388, 137240138, 142230122, 162221354, 163134117, 164808930, 172097268, 223785832, 226399521, 241084564, 250135219, 252141364, 252319440
Target and Pathway
Target(s) Dihydrofolate reductase Target Info Inhibitor [551393]
PathWhiz Pathway Folate Metabolism
Pterine Biosynthesis
Reactome E2F mediated regulation of DNA replication
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
Metabolism of folate and pterines
G1/S-Specific Transcription
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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