Drug Information

Drug General Information
Drug ID
D0P2ET
Former ID
DNC009466
Drug Name
Garveatin E
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528499]
Structure
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2D MOL

3D MOL
Formula
C20H20O5
Canonical SMILES
CCC1=C(C(=O)C2=CC3=C(C(=C(C(=O)C3(C)C)C)O)C(=C2C1=O)O)C
InChI
1S/C20H20O5/c1-6-10-8(2)15(21)11-7-12-14(18(24)13(11)17(10)23)16(22)9(3)19(25)20(12,4)5/h7,22,24H,6H2,1-5H3
InChIKey
XUTUGWZITVPISM-UHFFFAOYSA-N
PubChem Compound ID
16091659
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [528499]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 528499J Nat Prod. 2006 Oct;69(10):1496-9.Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.
Ref 528499J Nat Prod. 2006 Oct;69(10):1496-9.Indoleamine 2,3-dioxygenase inhibitors from the Northeastern Pacific Marine Hydroid Garveia annulata.

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