Drug Information

Drug General Information
Drug ID
D0K6ZA
Former ID
DIB018369
Drug Name
[3H]OSIP339391
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467776]
Structure
Download
2D MOL

3D MOL
Formula
C30H35N7O2
InChI
InChI=1S/C30H35N7O2/c1-22(38)31-14-15-32-28-25-21-26(33-29(25)35-27(34-28)24-12-6-3-7-13-24)30(39)37-19-17-36(18-20-37)16-8-11-23-9-4-2-5-10-23/h2-7,9-10,12-13,21H,8,11,14-20H2,1H3,(H,31,38)(H2,32,33,34,35)
InChIKey
MIUCZFWBCFZKEU-UHFFFAOYSA-N
PubChem Compound ID
5311041
PubChem Substance ID
7978888, 7980434, 11056227, 15192587, 39340770, 50308455, 57359335, 85209448, 103633572, 104114686, 114155118, 134346939, 135650781, 135651191, 140413383, 228651264, 249198991
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Antagonist [527107]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling Pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 467776(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 454).
Ref 527107[3H]OSIP339391, a selective, novel, and high affinity antagonist radioligand for adenosine A2B receptors. Biochem Pharmacol. 2004 Jul 15;68(2):305-12.

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