Drug Information

Drug General Information
Drug ID
D0Y3LW
Former ID
DIB018226
Drug Name
[3H]9-cis-retinoic acid
Synonyms
[3H]-9-cis-retinoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540795]
Formula
C20H28O2
InChI
InChI=1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8-,16-14+
InChIKey
SHGAZHPCJJPHSC-ZVCIMWCZSA-N
PubChem Compound ID
449171
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Agonist [534000]
Retinoid X receptor-beta Target Info Agonist [534000]
Retinoic acid receptor RXR-alpha Target Info Agonist [534000]
Retinoic acid receptor beta Target Info Agonist [534000]
Retinoic acid receptor RXR-gamma Target Info Agonist [534000]
Retinoic acid receptor gamma Target Info Agonist [534000]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemiahsa03320:PPAR signaling pathway
PI3K-Akt signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Bile secretion
Hepatitis C
Thyroid cancer
Small cell lung cancer
Non-small cell lung cancerhsa05200:Pathways in cancer
Non-small cell lung cancerhsa03320:PPAR signaling pathway
Non-small cell lung cancer
PANTHER Pathway Vitamin D metabolism and pathway
Pathway Interaction Database Retinoic acid receptors-mediated signalingar_tf_pathway:Regulation of Androgen receptor activity
RXR and RAR heterodimerization with other nuclear receptor
Retinoic acid receptors-mediated signaling
a6b1 and a6b4 Integrin signalingar_tf_pathway:Regulation of Androgen receptor activity
a6b1 and a6b4 Integrin signaling
Reactome Nuclear Receptor transcription pathwayR-HSA-1368082:RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Recycling of bile acids and salts
PPARA activates gene expression
Import of palmitoyl-CoA into the mitochondrial matrix
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Regulation of pyruvate dehydrogenase (PDH) complex
Endogenous sterols
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian ClockR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathwayR-HSA-383280:Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear ReceptorsWP716:Vitamin A and Carotenoid Metabolism
NRF2 pathway
Nuclear Receptors Meta-Pathway
Farnesoid X Receptor Pathway
PPAR Alpha Pathway
Vitamin D Receptor Pathway
Pregnane X Receptor pathway
Constitutive Androstane Receptor Pathway
Liver X Receptor Pathway
Regulation of Lipid Metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Transcriptional Regulation of White Adipocyte Differentiation
YAP1- and WWTR1 (TAZ)-stimulated gene expression
Activation of Gene Expression by SREBP (SREBF)
Circadian Clock
Nuclear Receptors
Vitamin D MetabolismWP716:Vitamin A and Carotenoid Metabolism
Mesodermal Commitment Pathway
Endoderm Differentiation
References
Ref 540795(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5383).
Ref 534000Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):30-4.

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