Drug General Information
Drug ID	D09NEP
Former ID	DIB020414
Drug Name	MRS1088
Synonyms	3,6-dichloroflavone; MRS-1088; NSC-74876
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[467628]
Structure		Download 2D MOL
Formula	C15H8Cl2O2
InChI	InChI=1S/C15H8Cl2O2/c16-10-6-7-12-11(8-10)14(18)13(17)15(19-12)9-4-2-1-3-5-9/h1-8H
InChIKey	PTNKLWUWHUGKTA-UHFFFAOYSA-N
PubChem Compound ID	252696
PubChem Substance ID	116622, 7703181, 9398640, 15818297, 30050799, 52967525, 103126828, 103274141, 103948332, 104448700, 117468271, 126469437, 135650641, 162785835, 249767477
Target and Pathway
Target(s)	Adenosine A3 receptor	Target Info	Antagonist	[534145]
	Adenosine A2b receptor	Target Info	Antagonist	[534145]
KEGG Pathway	Rap1 signaling pathway
	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Vascular smooth muscle contraction
	Alcoholism
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
	TCR Signaling Pathway
Pathway Interaction Database	C-MYB transcription factor network
PathWhiz Pathway	Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome	Adenosine P1 receptors
	G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
	G alpha (s) signalling events
	Surfactant metabolism
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	GPCRs, OtherWP80:Nucleotide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 467628	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 429).
Ref 534145	J Med Chem. 1996 Jun 7;39(12):2293-301.Synthesis and biological activities of flavonoid derivatives as A3 adenosine receptor antagonists.

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