Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04KQF
|
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| Former ID |
DNC001476
|
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| Drug Name |
Tubacin
|
||||
| Drug Type |
Small molecular drug
|
||||
| Indication | Multiple myeloma [ICD9: 203; ICD10:C90] | Investigative | [1] | ||
| Company |
Broad Institute
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C41H43N3O7S
|
||||
| InChI |
InChI=1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1
|
||||
| InChIKey |
BHUZLJOUHMBZQY-YXQOSMAKSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Histone deacetylase 6 | Target Info | Inhibitor | [2], [3] | |
| KEGG Pathway | Alcoholism | ||||
| Viral carcinogenesis | |||||
| Pathway Interaction Database | Signaling events mediated by HDAC Class II | ||||
| Signaling events mediated by HDAC Class I | |||||
| Reactome | NOTCH1 Intracellular Domain Regulates Transcription | ||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| Assembly of the primary cilium | |||||
| WikiPathways | Ectoderm Differentiation | ||||
| Neural Crest Differentiation | |||||
| Cell Cycle | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7374). | ||||
| REF 2 | Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006 Sep;5(9):769-84. | ||||
| REF 3 | Emerging therapies for multiple myeloma. Expert Opin Emerg Drugs. 2009 Mar;14(1):99-127. | ||||
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