Drug General Information
Drug ID	D0M2EZ
Former ID	DNC003600
Drug Name	KYS-05042
Indication	Discovery agent		Investigative	[529566]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Voltage-dependent T-type calcium channel alpha-1G subunit	Target Info	Inhibitor	[529566]
	Voltage-dependent T-type calcium channel subunit alpha-1H	Target Info	Inhibitor	[527099]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Circadian entrainment
	Type II diabetes mellitushsa04010:MAPK signaling pathway
PANTHER Pathway	Endogenous cannabinoid signaling
	GABA-B receptor II signaling
	Nicotine pharmacodynamics pathway
Pathway Interaction Database	Regulation of nuclear beta catenin signaling and target gene transcription
PathWhiz Pathway	Muscle/Heart ContractionPW000564:Muscle/Heart Contraction
Reactome	NCAM1 interactionsR-HSA-419037:NCAM1 interactions
WikiPathways	NCAM signaling for neurite out-growth
	Nicotine Activity on Chromaffin CellsWP2355:Corticotropin-releasing hormone
References
Ref 529566	Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.
Ref 527099	Bioorg Med Chem Lett. 2004 Jul 5;14(13):3379-84.3,4-Dihydroquinazoline derivatives as novel selective T-type Ca2+ channel blockers.
Ref 529566	Bioorg Med Chem Lett. 2008 Jul 15;18(14):3899-901. Epub 2008 Jun 14.T-type Ca2+ channel blockers suppress the growth of human cancer cells.

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