Drug Information

Drug General Information
Drug ID
D04PMQ
Former ID
DNCL003353
Drug Name
Brilinta/Brilique
Synonyms
EUCLID
Drug Type
Small molecular drug
Indication Arterial thrombosis; Myocardial infarction [ICD9: 437.6, 453, 671.5, 671.9, 410; ICD10:I80-I82, I21, I22] Phase 3 [524133]
Company
AstraZeneca
Structure
Download
2D MOL

3D MOL
Formula
C23H28F2N6O4S
Canonical SMILES
CCCSC1=NC2=C(C(=N1)NC3CC3C4=CC(=C(C=C4)F)F)N=NN2C5CC(C(<br />C5O)O)OCCO
InChI
1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
InChIKey
OEKWJQXRCDYSHL-FNOIDJSQSA-N
PubChem Compound ID
9871419
PubChem Substance ID
14836432, 14860737, 24162024, 45293678, 49684205, 57373617, 77877844, 92729712, 96025700, 103554312, 123051091, 124759706, 126644885, 126666051, 135649975, 136345665, 137171656, 139857160, 152040158, 152258075, 160645837, 160646914, 162011636, 163346229, 163383616, 164178089, 164765598, 165245536, 170501033, 171063069, 172914585, 174528632, 175267325, 175427101, 185974765, 189657701, 198993342, 211534943, 223384813, 223666650, 224638556, 228139491, 247988848, 249582784, 249807649, 249807650, 249816423, 251966736, 251970939, 252216468
Target and Pathway
Target(s) P2Y purinoceptor 12 Target Info Modulator [543771]
KEGG Pathway Platelet activation
Reactome P2Y receptors
G alpha (i) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 524133ClinicalTrials.gov (NCT01732822) A Study Comparing Cardiovascular Effects of Ticagrelor and Clopidogrel in Patients With Peripheral Artery Disease. U.S. National Institutes of Health.
Ref 543771(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 328).

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