Drug Information

Drug General Information
Drug ID
D07MEH
Former ID
DAP001495
Drug Name
Meglitinides
Drug Type
Small molecular drug
Indication Hyperglycaemia in type 2 diabetes [ICD9: 250, 790.29; ICD10:E11, R73.9] Approved [536873]
Structure
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2D MOL

3D MOL
Formula
C15H20Cl2N2O3
Canonical SMILES
CCN1CCCC1CNC(=O)C2=C(C(=CC(=C2OC)Cl)Cl)O
InChI
1S/C15H20Cl2N2O3/c1-3-19-6-4-5-9(19)8-18-15(21)12-13(20)10(16)7-11(17)14(12)22-2/h7,9,20H,3-6,8H2,1-2H3,(H,18,21)/t9-/m0/s1
InChIKey
WAOQONBSWFLFPE-VIFPVBQESA-N
PubChem Compound ID
3033769
PubChem Substance ID
7980481, 10047782, 11114224, 12013470, 14827538, 26719717, 26752250, 36077621, 46386981, 47515551, 47810996, 48185204, 49681662, 50104962, 53787975, 57352765, 77953791, 85788759, 90340860, 91746408, 92308273, 92308736, 103167993, 103918664, 111634979, 124658776, 124800057, 124887054, 129553949, 134338685, 134340417, 135014074, 135650880, 135698402, 137237422, 142971008, 144204512, 152106370, 160821969, 162023238, 163091727, 163383825, 170466218, 170485724, 172080125, 172860716, 176484026, 178100336, 179151282, 198978423
Target and Pathway
Target(s) Insulin receptor Target Info Stimulator [536873]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
NetPath Pathway TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathway
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transport
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin Signaling
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recycling
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK Signaling
References
Ref 536873New drugs for type 2 diabetes mellitus: what is their place in therapy? Drugs. 2008;68(15):2131-62.
Ref 536873New drugs for type 2 diabetes mellitus: what is their place in therapy? Drugs. 2008;68(15):2131-62.

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