Drug Information

Drug General Information
Drug ID
D0S6TK
Former ID
DIB018041
Drug Name
tamatinib
Synonyms
R 406; R-406; R406 free base
Drug Type
Small molecular drug
Indication Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] Clinical trial [536998]
Structure
Download
2D MOL
Formula
C22H23FN6O5
InChI
InChI=1S/C22H23FN6O5/c1-22(2)20(30)28-19-13(34-22)6-7-16(27-19)26-18-12(23)10-24-21(29-18)25-11-8-14(31-3)17(33-5)15(9-11)32-4/h6-10H,1-5H3,(H3,24,25,26,27,28,29,30)
InChIKey
NHHQJBCNYHBUSI-UHFFFAOYSA-N
PubChem Compound ID
11213558
PubChem Substance ID
16296087, 23397780, 42293201, 50077030, 57288231, 77344609, 99443630, 99460878, 103596121, 103904600, 103911497, 104103809, 104253192, 118049697, 121279875, 124772082, 126659679, 126726736, 135686088, 135686089, 135686106, 135686107, 135727442, 136367807, 136920409, 137275829, 141853025, 143498000, 152090530, 152234883, 152258324, 152344022, 160647163, 160968244, 162011591, 162202555, 162202679, 162920174, 164041983, 164824515, 170482429, 170483678, 170485720, 170496629, 170498439, 172912587, 174530755, 177748686, 178102333, 180190838
Target and Pathway
Target(s) Tyrosine-protein kinase SYK Target Info Inhibitor [529992]
Proto-oncogene tyrosine-protein kinase receptor ret Target Info Inhibitor [536998]
KEGG Pathway NF-kappa B signaling pathway
PI3K-Akt signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Tuberculosis
Epstein-Barr virus infection
Viral carcinogenesishsa04144:Endocytosis
Pathways in cancer
Thyroid cancer
Central carbon metabolism in cancer
PANTHER Pathway B cell activation
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
BCR signaling pathway
GMCSF-mediated signaling events
Atypical NF-kappaB pathway
Osteopontin-mediated events
FAS (CD95) signaling pathway
Thromboxane A2 receptor signaling
IL2-mediated signaling events
Class I PI3K signaling events
Alpha-synuclein signalingret_pathway:Signaling events regulated by Ret tyrosine kinase
Posttranslational regulation of adherens junction stability and dissassembly
PathWhiz Pathway Fc Epsilon Receptor I Signaling in Mast Cells
Reactome GPVI-mediated activation cascade
FCGR activation
Regulation of actin dynamics for phagocytic cup formation
Role of phospholipids in phagocytosis
DAP12 signaling
Fc epsilon receptor (FCERI) signaling
Role of LAT2/NTAL/LAB on calcium mobilization
FCERI mediated MAPK activation
FCERI mediated Ca+2 mobilization
Integrin alphaIIb beta3 signaling
Interleukin-2 signaling
CLEC7A (Dectin-1) signaling
Dectin-2 family
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways IL-2 Signaling Pathway
IL-3 Signaling Pathway
Fc epsilon receptor (FCERI) signaling
Signaling by the B Cell Receptor (BCR)
Interleukin-2 signaling
Fcgamma receptor (FCGR) dependent phagocytosis
DAP12 interactions
B Cell Receptor Signaling Pathway
RANKL/RANK Signaling Pathway
Integrin alphaIIb beta3 signaling
GPVI-mediated activation cascade
Regulation of toll-like receptor signaling pathway
IL-5 Signaling PathwayWP706:SIDS Susceptibility Pathways
Dopaminergic Neurogenesis
References
Ref 536998Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):130-6.
Ref 529992Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1944-9.
Ref 536998Developmental toxicity associated with receptor tyrosine kinase Ret inhibition in reproductive toxicity testing. Birth Defects Res A Clin Mol Teratol. 2009 Feb;85(2):130-6.

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