Drug Information

Drug General Information
Drug ID
D0D8FE
Former ID
DNC009457
Drug Name
Guttiferone I
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527525]
Structure
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2D MOL

3D MOL
Formula
C43H58O6
Canonical SMILES
CC(=CCCC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(<br />C2=O)(C1(C)CCC=C(C)C)CC=C(C)C)CC=C(C)C)C)C
InChI
1S/C43H58O6/c1-27(2)13-11-15-31(9)16-18-33-26-42(23-20-29(5)6)38(47)36(37(46)32-17-19-34(44)35(45)25-32)39(48)43(40(42)49,24-21-30(7)8)41(33,10)22-12-14-28(3)4/h13-14,16-17,19-21,25,33,44-46H,11-12,15,18,22-24,26H2,1-10H3/b31-16+,37-36+/t33-,41+,42-,43+/m0/s1
InChIKey
HIGOXQQRSUDJCL-KJLWUZBSSA-N
PubChem Compound ID
44584005
Target and Pathway
Target(s) Oxysterols receptor LXR-alpha Target Info Inhibitor [527525]
KEGG Pathway PPAR signaling pathway
Non-alcoholic fatty liver disease (NAFLD)
Hepatitis C
Pathway Interaction Database RXR and RAR heterodimerization with other nuclear receptor
WikiPathways Nuclear Receptors in Lipid Metabolism and Toxicity
Nuclear Receptors Meta-Pathway
PPAR Alpha Pathway
Liver X Receptor Pathway
Adipogenesis
SREBF and miR33 in cholesterol and lipid homeostasis
Nuclear Receptors
References
Ref 527525J Nat Prod. 2005 Apr;68(4):617-9.Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.
Ref 527525J Nat Prod. 2005 Apr;68(4):617-9.Guttiferone I, a new prenylated benzophenone from Garcinia humilis as a liver X receptor ligand.

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