TTD | Drug: D0S3NS

Drug General Information
Drug ID	D0S3NS
Former ID	DIB018520
Drug Name	2-(indolin-1yl)-melatonin
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[542734]
Structure		Download 2D MOL
Formula	C22H25N3O2
InChI	InChI=1S/C22H25N3O2/c1-15(26)23-11-9-18-19-13-17(27-2)7-8-20(19)24-21(18)14-25-12-10-16-5-3-4-6-22(16)25/h3-8,13,24H,9-12,14H2,1-2H3,(H,23,26)
InChIKey	WPMBIMXWTHXWHN-UHFFFAOYSA-N
PubChem Compound ID	25210130
PubChem Substance ID	57417179, 85046896, 103630292, 104113803, 223366115, 248928188
Target and Pathway
Target(s)	Melatonin receptor	Target Info	Antagonist	[529949]
KEGG Pathway	Neuroactive ligand-receptor interaction
KEGG Pathway	Circadian entrainment
Reactome	Class A/1 (Rhodopsin-like receptors)
Reactome	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 542734	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7782).
Ref 529949	J Med Chem. 2009 Feb 12;52(3):826-33.2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists.

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Drug Information