Drug Information

Drug General Information
Drug ID
D0C2UJ
Former ID
DIB018545
Drug Name
2-chloroadenosine
Synonyms
2Cl-Ado; CADO
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540506]
Structure
Download
2D MOL
Formula
C10H12ClN5O4
InChI
InChI=1S/C10H12ClN5O4/c11-10-14-7(12)4-8(15-10)16(2-13-4)9-6(19)5(18)3(1-17)20-9/h2-3,5-6,9,17-19H,1H2,(H2,12,14,15)/t3-,5-,6-,9-/m1/s1
InChIKey
BIXYYZIIJIXVFW-UUOKFMHZSA-N
PubChem Compound ID
8974
PubChem Substance ID
219276, 593313, 855580, 7978576, 8156381, 15271562, 24277688, 26751454, 29227601, 46386960, 47285828, 47434822, 48105155, 48105156, 48253923, 48404448, 49831028, 49865074, 50103933, 50103934, 56463001, 57325350, 71822869, 76715591, 77289049, 90341035, 91691266, 92308272, 93621370, 103201179, 103922536, 104319213, 119526173, 124659049, 124801273, 124999963, 125085401, 126669763, 127522371, 134974935, 135173015, 135651395, 136380290, 136990731, 141476773, 143489750, 144089040, 152036336, 152134715, 152242413
Target and Pathway
Target(s) Adenosine A2b receptor Target Info Agonist [533531]
Adenosine A1 receptor Target Info Agonist [534823]
Adenosine A3 receptor Target Info Agonist [533853]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Alcoholismhsa04022:cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Morphine addiction
NetPath Pathway TGF_beta_Receptor Signaling Pathway
TCR Signaling PathwayNetPath_11:TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolismR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCRs, Other
References
Ref 540506(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 372).
Ref 533531Adenosine receptor activation in human fibroblasts: nucleoside agonists and antagonists. Can J Physiol Pharmacol. 1980 Jun;58(6):673-91.
Ref 533853A binding site model and structure-activity relationships for the rat A3 adenosine receptor. Mol Pharmacol. 1994 Jun;45(6):1101-11.
Ref 534823Identification of the adenine binding site of the human A1 adenosine receptor. J Biol Chem. 1999 Feb 5;274(6):3617-21.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.