Drug General Information
Drug ID
D0J2VB
Former ID
DCL000534
Drug Name
Iboctadekin + rituximab
Drug Type
Antibody
Indication Non-hodgkin's lymphoma; Follicular lymphoma [ICD9: 200, 202, 202.0, 202.8; ICD10:C81-C86, C82, C82-C85] Phase 1 [549706]
Company
GSK
Structure
Download
2D MOL

3D MOL

Formula
C34H63N5O9
Canonical SMILES
CC(C)CC(C(CC(=O)O)O)NC(=O)C(C)NC(=O)CC(C(CC(C)C)NC(=O)C<br />(C(C)C)NC(=O)C(C(C)C)NC(=O)CC(C)C)O
InChI
1S/C34H63N5O9/c1-17(2)12-23(37-33(47)31(21(9)10)39-34(48)30(20(7)8)38-27(42)14-19(5)6)25(40)15-28(43)35-22(11)32(46)36-24(13-18(3)4)26(41)16-29(44)45/h17-26,30-31,40-41H,12-16H2,1-11H3,(H,35,43)(H,36,46)(H,37,47)(H,38,42)(H,39,48)(H,44,45)/t22-,23-,24-,25-,26-,30-,31-/m0/s1
InChIKey
FAXGPCHRFPCXOO-LXTPJMTPSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Interleukin-18 Target Info Modulator [550963]
B-lymphocyte antigen CD20 Target Info [550963]
KEGG Pathway Cytokine-cytokine receptor interaction
NOD-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Salmonella infection
Legionellosis
African trypanosomiasis
Malaria
Tuberculosis
Influenza A
Inflammatory bowel disease (IBD)
Rheumatoid arthritishsa04640:Hematopoietic cell lineage
NetPath Pathway IL4 Signaling Pathway
PANTHER Pathway Interleukin signaling pathway
Toll receptor signaling pathway
Pathway Interaction Database IL27-mediated signaling events
IL12-mediated signaling events
IL23-mediated signaling events
Cellular roles of Anthrax toxin
IL12 signaling mediated by STAT4
Reactome Interleukin-1 processing
WikiPathways Hypertrophy Model
IL1 and megakaryotyces in obesity
Corticotropin-releasing hormone
NOD pathway
References
Ref 549706J Clin Oncol 27:15s, 2009 (suppl, abstr 8566).
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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