Drug Information

Drug General Information
Drug ID
D03HVE
Former ID
DNC002561
Drug Name
Hypoxanthine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [467792]
Structure
Download
2D MOL

3D MOL
Formula
C5H4N4O
InChI
InChI=1S/C5H4N4O/c10-5-3-4(7-1-6-3)8-2-9-5/h1-2H,(H2,6,7,8,9,10)
InChIKey
FDGQSTZJBFJUBT-UHFFFAOYSA-N
CAS Number
CAS 68-94-0
PubChem Compound ID
790
PubChem Substance ID
2813, 3560, 540767, 589179, 618936, 3133523, 5248991, 6282154, 6356782, 6380308, 7888201, 8144165, 10532804, 11088539, 11341732, 11361915, 11364311, 11366873, 11369435, 11372482, 11375322, 11377597, 11485610, 11487317, 11489723, 11491167, 11493556, 11495231, 11536560, 11538005, 14747719, 15016626, 16142119, 16769078, 16997017, 22389259, 24439150, 24895400, 24895850, 24895864, 26613338, 26679242, 26702295, 26702297, 26702301, 26707407, 26707409, 26707413, 26710045, 26710449
Target and Pathway
Target(s) Purine nucleoside phosphorylase Target Info Inhibitor [551393]
BioCyc Pathway Arsenate detoxification I (glutaredoxin)
Purine nucleotides degradation
Urate biosynthesis/inosine 5'-phosphate degradation
Purine deoxyribonucleosides degradation
Purine ribonucleosides degradation to ribose-1-phosphate
Guanosine nucleotides degradation
Adenosine nucleotides degradation
Superpathway of purine nucleotide salvage
Adenine and adenosine salvage III
Guanine and guanosine salvage
KEGG Pathway Purine metabolism
Pyrimidine metabolism
Nicotinate and nicotinamide metabolism
Metabolic pathways
NetPath Pathway TCR Signaling Pathway
EGFR1 Signaling Pathway
PANTHER Pathway Adenine and hypoxanthine salvage pathway
Xanthine and guanine salvage pathway
PathWhiz Pathway Purine Metabolism
Nicotinate and Nicotinamide Metabolism
Reactome Purine salvage
Purine catabolism
WikiPathways miR-targeted genes in squamous cell - TarBase
miR-targeted genes in lymphocytes - TarBase
miR-targeted genes in leukocytes - TarBase
miR-targeted genes in epithelium - TarBase
Metabolism of nucleotides
References
Ref 467792(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4555).
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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