Drug General Information
Drug ID	D00PLH
Former ID	DNC007667
Drug Name	1,2-bis(2,5-difluorophenyl)-2-hydroxyethanone
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[528766]
Structure		Download 2D MOL 3D MOL
Formula	C14H8F4O2
Canonical SMILES	C1=CC(=C(C=C1F)C(C(=O)C2=C(C=CC(=C2)F)F)O)F
InChI	1S/C14H8F4O2/c15-7-1-3-11(17)9(5-7)13(19)14(20)10-6-8(16)2-4-12(10)18/h1-6,13,19H
InChIKey	DMPZBXMNYCXAQZ-UHFFFAOYSA-N
PubChem Compound ID	44428832
Target and Pathway
Target(s)	Liver carboxylesterase	Target Info	Inhibitor	[528766]
KEGG Pathway	Drug metabolism - other enzymes
	Metabolic pathways
Pathway Interaction Database	E2F transcription factor network
WikiPathways	NRF2 pathway
	Nuclear Receptors Meta-Pathway
	Heroin metabolism
	Irinotecan Pathway
	Fluoropyrimidine Activity
	Phase I biotransformations, non P450
References
Ref 528766	Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.
Ref 528766	Bioorg Med Chem. 2007 Jun 1;15(11):3801-17. Epub 2007 Mar 12.Analysis of the inhibition of mammalian carboxylesterases by novel fluorobenzoins and fluorobenzils.

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