Drug Information

Drug General Information
Drug ID
D0D0DW
Former ID
DNC004755
Drug Name
1-(4-Bromo-benzyl)-3-quinazolin-8-yl-urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527423]
Structure
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2D MOL

3D MOL
Formula
C16H13BrN4O
Canonical SMILES
C1=CC2=CN=CN=C2C(=C1)NC(=O)NCC3=CC=C(C=C3)Br
InChI
1S/C16H13BrN4O/c17-13-6-4-11(5-7-13)8-19-16(22)21-14-3-1-2-12-9-18-10-20-15(12)14/h1-7,9-10H,8H2,(H2,19,21,22)
InChIKey
HUPXBWYDCNIXNH-UHFFFAOYSA-N
PubChem Compound ID
11302766
Target and Pathway
Target(s) Vanilloid receptor 1 Target Info Inhibitor [527423]
KEGG Pathway Neuroactive ligand-receptor interaction
Inflammatory mediator regulation of TRP channels
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Trk receptor signaling mediated by the MAPK pathway
Trk receptor signaling mediated by PI3K and PLC-gamma
Reactome TRP channels
References
Ref 527423J Med Chem. 2005 Feb 10;48(3):744-52.Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
Ref 527423J Med Chem. 2005 Feb 10;48(3):744-52.Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.

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