Drug Information
Drug General Information | |||||
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Drug ID |
D0R1FZ
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Former ID |
DIB020258
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Drug Name |
LXA4
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Synonyms |
5,6,15-triHETE ; lipoxin A4
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [538629] | ||
Structure |
Download2D MOL |
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Formula |
C20H32O5
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InChI |
InChI=1S/C20H32O5/c1-2-3-8-12-17(21)13-9-6-4-5-7-10-14-18(22)19(23)15-11-16-20(24)25/h4-7,9-10,13-14,17-19,21-23H,2-3,8,11-12,15-16H2,1H3,(H,24,25)/b6-4-,7-5+,13-9+,14-10+/t17-,18+,19-/m0/s1
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InChIKey |
IXAQOQZEOGMIQS-SSQFXEBMSA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
8550, 4266097, 8616440, 14717862, 14900949, 14925511, 24896257, 26754801, 26754802, 39289895, 47439991, 48110204, 50110782, 57357927, 76715551, 79177356, 92309794, 99300708, 99302226, 103543153, 104046428, 113854224, 126525082, 135308855, 135651504, 137006644, 140337479, 162227012, 164758015, 179205550, 241153138, 252455518, 252467993
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Target and Pathway | |||||
Target(s) | FMLP-related receptor I | Target Info | Agonist | [530641] | |
GPR32 | Target Info | Agonist | [530641] | ||
FPR3 | Target Info | Agonist | [534386] | ||
Pathway Interaction Database | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling | ||||
References | |||||
Ref 530641 | Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A. 2010 Jan 26;107(4):1660-5. | ||||
Ref 534386 | Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. J Exp Med. 1997 May 5;185(9):1693-704. |
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