| Drug General Information |
| Drug ID |
D01DFX
|
| Former ID |
DNC014518
|
| Drug Name |
4-[(2-Methyl-1H-imidazol-1-yl)methyl]pyridine
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C10H11N3
|
| Canonical SMILES |
CC1=NC=CN1CC2=CC=NC=C2
|
| InChI |
1S/C10H11N3/c1-9-12-6-7-13(9)8-10-2-4-11-5-3-10/h2-7H,8H2,1H3
|
| InChIKey |
MNSNMTASPOHKEI-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
|---|
| Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
|
|
KEGG Pathway
|
Arginine and proline metabolism
|
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Metabolic pathways
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Calcium signaling pathway
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Phagosome
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Circadian entrainment
|
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Long-term depression
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Salivary secretion
|
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Alzheimer's disease
|
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Amyotrophic lateral sclerosis (ALS)hsa00220:Arginine biosynthesis
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HIF-1 signaling pathway
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Peroxisome
|
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Salmonella infection
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Pertussis
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Leishmaniasis
|
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
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Pathways in cancer
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Small cell lung cancer
|
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NetPath Pathway
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EGFR1 Signaling PathwayNetPath_13:IL1 Signaling Pathway
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IL2 Signaling Pathway
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PANTHER Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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IL12-mediated signaling events
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Alpha9 beta1 integrin signaling events
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ATF-2 transcription factor network
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IL23-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Arginine and Proline Metabolism
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Reactome
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ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
|
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Nitric oxide stimulates guanylate cyclase
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WikiPathways
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Monoamine Transport
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Myometrial Relaxation and Contraction Pathways
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Amyotrophic lateral sclerosis (ALS)
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Spinal Cord Injury
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Alzheimers Disease
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Effects of Nitric Oxide
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Serotonin Transporter ActivityWP619:Type II interferon signaling (IFNG)
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AGE/RAGE pathway
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| References |
| REF 1 | Bioorg Med Chem Lett. 2010 Nov 15;20(22):6495-9. Epub 2010 Sep 17.N-Substituted acetamidines and 2-methylimidazole derivatives as selective inhibitors of neuronal nitric oxide synthase. |
|---|
