Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0H2NT
|
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| Former ID |
DNC012113
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| Drug Name |
MK-056
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [530533] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C20H27N3O2S2
|
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| Canonical SMILES |
CC(C)(C)C1=CC=C(C=C1)CNC(=S)NCC2=CC=C(C=C2)NS(=O)(=O)C
|
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| InChI |
1S/C20H27N3O2S2/c1-20(2,3)17-9-5-15(6-10-17)13-21-19(26)22-14-16-7-11-18(12-8-16)23-27(4,24)25/h5-12,23H,13-14H2,1-4H3,(H2,21,22,26)
|
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| InChIKey |
LOMAEJPLJSUBML-UHFFFAOYSA-N
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Transient receptor potential cation channel subfamily V member 4 | Target Info | Inhibitor | [526897] | |
| Vanilloid receptor 1 | Target Info | Inhibitor | [530533] | ||
| Vanilloid receptor | Target Info | Inhibitor | [530533] | ||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| References | |||||
| Ref 526897 | Bioorg Med Chem Lett. 2003 Dec 15;13(24):4389-93.Novel non-vanilloid VR1 antagonist of high analgesic effects and its structural requirement for VR1 antagonistic effects. | ||||
| Ref 530533 | Bioorg Med Chem. 2010 Jan 1;18(1):111-6. Epub 2009 Nov 10.Silicon switch approach in TRPV1 antagonist MK-056 and its analogues. | ||||
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