Drug Information

Drug General Information
Drug ID
D0G4GB
Former ID
DIB020604
Drug Name
omega-chloroacetophenone
Synonyms
mace (lacrimator); tear gas; phenacyl chloride; chloromethyl phenyl ketone
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541436]
Structure
Download
2D MOL
Formula
C8H7ClO
InChI
InChI=1S/C8H7ClO/c9-6-8(10)7-4-2-1-3-5-7/h1-5H,6H2
InChIKey
IMACFCSSMIZSPP-UHFFFAOYSA-N
PubChem Compound ID
10757
PubChem Substance ID
96446, 3132350, 7776646, 8157790, 10525594, 11108627, 12078969, 15091111, 17389975, 24887196, 24892454, 26752938, 29229219, 48413428, 48421387, 48422357, 48424953, 49854413, 53787817, 57326443, 80183170, 88561139, 90341936, 99217986, 103321621, 104324182, 104749200, 117470385, 117470386, 117564255, 118307953, 124890596, 124890597, 124890598, 125308706, 125352338, 126553723, 126588922, 126612597, 126689020, 127275463, 127275464, 127275465, 127275466, 127275467, 127275468, 127275469, 127275470, 127275471, 127275472
Target and Pathway
Target(s) Transient receptor potential cation channel subfamily A member 1 Target Info Activator [529493]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Reactome TRP channels
References
Ref 541436(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6285).
Ref 529493Tear gasses CN, CR, and CS are potent activators of the human TRPA1 receptor. Toxicol Appl Pharmacol. 2008 Sep 1;231(2):150-6.

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