Drug Information
Drug General Information | |||||
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Drug ID |
D0M4IE
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Former ID |
DNC009842
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Drug Name |
Bis-7-tacrine
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Synonyms |
Bis(7)-tacrine
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [530923] | ||
Structure |
Download2D MOL |
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Formula |
C33H40N4
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Acetylcholinesterase | Target Info | Inhibitor | [530923] | |
Beta-secretase | Target Info | Inhibitor | [530301] | ||
Cholinesterase | Target Info | Inhibitor | [530923] | ||
KEGG Pathway | Glycerophospholipid metabolism | ||||
Cholinergic synapse | |||||
PANTHER Pathway | Muscarinic acetylcholine receptor 1 and 3 signaling pathway | ||||
Muscarinic acetylcholine receptor 2 and 4 signaling pathway | |||||
Nicotinic acetylcholine receptor signaling pathwayP00042:Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
Nicotinic acetylcholine receptor signaling pathway | |||||
Pathway Interaction Database | ATF-2 transcription factor network | ||||
PathWhiz Pathway | Phospholipid Biosynthesis | ||||
References | |||||
Ref 530301 | J Med Chem. 2009 Sep 10;52(17):5365-79.Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds. | ||||
Ref 530923 | Bioorg Med Chem Lett. 2010 Jun 15;20(12):3606-9. Epub 2010 Apr 28.Design, synthesis and evaluation of 2,4-disubstituted pyrimidines as cholinesterase inhibitors. |
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