Drug Information

Drug General Information
Drug ID
D0O5ZY
Former ID
DNC000962
Drug Name
MRS-2179
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539072]
Structure
Download
2D MOL

3D MOL
Formula
C11H15N5O9P2-2
InChI
InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/p-2/t6-,7+,8+/m0/s1
InChIKey
CCPLITQNIFLYQB-XLPZGREQSA-L
CAS Number
CAS 63142-71-2
PubChem Compound ID
24867852
PubChem Substance ID
50111133, 90341270, 124749972, 135650654
SuperDrug ATC ID
J05AB04
SuperDrug CAS ID
cas=036791045
Target and Pathway
Target(s) P2Y purinoceptor 1 Target Info Antagonist [535699], [535768]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signaling
References
Ref 539072(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1720).
Ref 535699The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179. Cardiovasc Drug Rev. 2003 Spring;21(1):67-76.
Ref 535768Inhibition of localized thrombosis in P2Y1-deficient mice and rodents treated with MRS2179, a P2Y1 receptor antagonist. J Thromb Haemost. 2003 Jun;1(6):1144-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.