| Drug General Information |
| Drug ID |
D0C3CS
|
| Former ID |
DNC014163
|
| Drug Name |
4,5,6,7-tetrafluoro-3-methyl-1H-indazole
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C8H4F4N2
|
| Canonical SMILES |
CC1=C2C(=C(C(=C(C2=NN1)F)F)F)F
|
| InChI |
1S/C8H4F4N2/c1-2-3-4(9)5(10)6(11)7(12)8(3)14-13-2/h1H3,(H,13,14)
|
| InChIKey |
MEHLPQAUVAMMPE-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Nitric oxide synthase, inducible |
Target Info |
Inhibitor |
[1]
|
|---|
| Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
|
|
KEGG Pathway
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Arginine biosynthesis
|
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Arginine and proline metabolism
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Metabolic pathways
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Calcium signaling pathway
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HIF-1 signaling pathway
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Peroxisome
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Salmonella infection
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Pertussis
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Leishmaniasis
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Chagas disease (American trypanosomiasis)
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Toxoplasmosis
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Amoebiasis
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Tuberculosis
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Pathways in cancer
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Small cell lung cancerhsa00330:Arginine and proline metabolism
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Phagosome
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Circadian entrainment
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Long-term depression
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Salivary secretion
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Alzheimer's disease
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Amyotrophic lateral sclerosis (ALS)
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NetPath Pathway
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IL1 Signaling Pathway
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IL2 Signaling PathwayNetPath_4:EGFR1 Signaling Pathway
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PANTHER Pathway
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CCKR signaling map ST
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Pathway Interaction Database
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IL12-mediated signaling events
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Alpha9 beta1 integrin signaling events
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ATF-2 transcription factor network
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IL23-mediated signaling events
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Signaling mediated by p38-alpha and p38-beta
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HIF-1-alpha transcription factor network
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PathWhiz Pathway
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Arginine and Proline Metabolism
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Reactome
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ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
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Nitric oxide stimulates guanylate cyclase
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WikiPathways
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Type II interferon signaling (IFNG)
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Spinal Cord Injury
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AGE/RAGE pathway
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Effects of Nitric OxideWP727:Monoamine Transport
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Myometrial Relaxation and Contraction Pathways
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Amyotrophic lateral sclerosis (ALS)
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
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Alzheimers Disease
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Effects of Nitric Oxide
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Serotonin Transporter Activity
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| References |
| REF 1 | Bioorg Med Chem. 2009 Sep 1;17(17):6180-7. Epub 2009 Aug 6.Fluorinated indazoles as novel selective inhibitors of nitric oxide synthase (NOS): synthesis and biological evaluation. |
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