Drug General Information
Drug ID	D03LRQ
Former ID	DNC014204
Drug Name	2-(3-benzoyl-1H-pyrrol-1-yl)acetic acid
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[530758]
Structure		Download 2D MOL 3D MOL
Formula	C13H11NO3
Canonical SMILES	C1=CC=C(C=C1)C(=O)C2=CN(C=C2)CC(=O)O
InChI	1S/C13H11NO3/c15-12(16)9-14-7-6-11(8-14)13(17)10-4-2-1-3-5-10/h1-8H,9H2,(H,15,16)
InChIKey	NFEXRSVGIRNYEZ-UHFFFAOYSA-N
PubChem Compound ID	10398922
Target and Pathway
Target(s)	Aldose reductase	Target Info	Inhibitor	[530758]
BioCyc Pathway	Methylglyoxal degradation III
	Acetone degradation I (to methylglyoxal)
KEGG Pathway	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Glycerolipid metabolism
	Metabolic pathways
NetPath Pathway	IL1 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway	Fructose and Mannose Degradation
	Pyruvate Metabolism
	Pterine Biosynthesis
	Glycerolipid Metabolism
	Galactose Metabolism
WikiPathways	Metapathway biotransformation
	Polyol Pathway
	Metabolism of steroid hormones and vitamin D
References
Ref 530758	Bioorg Med Chem. 2010 Mar 15;18(6):2107-14. Epub 2010 Feb 11.Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case ofbioisosterism between a carboxylic acid moiety and that of a tetrazole.
Ref 530758	Bioorg Med Chem. 2010 Mar 15;18(6):2107-14. Epub 2010 Feb 11.Design and synthesis of novel series of pyrrole based chemotypes and their evaluation as selective aldose reductase inhibitors. A case ofbioisosterism between a carboxylic acid moiety and that of a tetrazole.

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