Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0FN5D
|
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| Former ID |
DNC009949
|
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| Drug Name |
2,2-bis(4-fluorophenyl)-N-hydroxyacetamide
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C14H11F2NO2
|
||||
| Canonical SMILES |
C1=CC(=CC=C1C(C2=CC=C(C=C2)F)C(=O)NO)F
|
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| InChI |
1S/C14H11F2NO2/c15-11-5-1-9(2-6-11)13(14(18)17-19)10-3-7-12(16)8-4-10/h1-8,13,19H,(H,17,18)
|
||||
| InChIKey |
HHJNWMNXSDYVHL-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| Target and Pathway | |||||
| Target(s) | Histone deacetylase | Target Info | Inhibitor | [1] | |
| Histone deacetylase 4 | Target Info | Inhibitor | [1] | ||
| KEGG Pathway | Alcoholism | ||||
| Epstein-Barr virus infection | |||||
| Viral carcinogenesis | |||||
| MicroRNAs in cancer | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Signaling events mediated by HDAC Class II | ||||
| Signaling events mediated by HDAC Class III | |||||
| Signaling events mediated by HDAC Class I | |||||
| Sumoylation by RanBP2 regulates transcriptional repression | |||||
| Validated nuclear estrogen receptor alpha network | |||||
| Reactome | NOTCH1 Intracellular Domain Regulates Transcription | ||||
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | |||||
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | |||||
| WikiPathways | Endochondral Ossification | ||||
| Cardiac Hypertrophic Response | |||||
| Neural Crest Differentiation | |||||
| miR-targeted genes in muscle cell - TarBase | |||||
| miR-targeted genes in lymphocytes - TarBase | |||||
| miR-targeted genes in epithelium - TarBase | |||||
| TarBasePathway | |||||
| Cell Cycle | |||||
| MicroRNAs in cardiomyocyte hypertrophy | |||||
| References | |||||
| REF 1 | Bioorg Med Chem Lett. 2009 Oct 1;19(19):5684-8. Epub 2009 Aug 7.Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors. | ||||
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