TTD | Drug: D0A3DE

Drug General Information
Drug ID	D0A3DE
Former ID	DIB018332
Drug Name	[3H]meclinertant
Synonyms	[3H]-SR48692; [3H]reminertant; [3H]SR-48692
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[538962]
Structure		Download 2D MOL
Formula	C32H31ClN4O5
InChI	InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)/i1T3,2T3
InChIKey	DYLJVOXRWLXDIG-VQBNBCTGSA-N
PubChem Compound ID	53323315
PubChem Substance ID	124969483, 135651210
Target and Pathway
Target(s)	Neurotensin receptor type 1	Target Info	Antagonist	[533717]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	Peptide ligand-binding receptors
Reactome	G alpha (q) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 538962	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1583).
Ref 533717	[3H]SR 48692, the first nonpeptide neurotensin antagonist radioligand: characterization of binding properties and evidence for distinct agonist and antagonist binding domains on the rat neurotensin receptor. Mol Pharmacol. 1995 May;47(5):1050-6.

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Drug Information