Drug General Information
Drug ID	D0UI8Q
Former ID	DNC004484
Drug Name	5-Bromo-8-imidazol-1-ylmethyl-chromen-4-one
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[535139]
Structure		Download 2D MOL 3D MOL
Formula	C13H9BrN2O2
Canonical SMILES	C1=CC(=C2C(=O)C=COC2=C1CN3C=CN=C3)Br
InChI	1S/C13H9BrN2O2/c14-10-2-1-9(7-16-5-4-15-8-16)13-12(10)11(17)3-6-18-13/h1-6,8H,7H2
InChIKey	QYFIAVSWVXIKAW-UHFFFAOYSA-N
PubChem Compound ID	10566470
Target and Pathway
Target(s)	Cytochrome P450 19	Target Info	Inhibitor	[535139]
BioCyc Pathway	Superpathway of steroid hormone biosynthesis
	Estradiol biosynthesis II
	Estradiol biosynthesis I
KEGG Pathway	Steroid hormone biosynthesis
	Metabolic pathways
	Ovarian steroidogenesis
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway	Androgen and Estrogen Metabolism
Reactome	Endogenous sterols
WikiPathways	Metapathway biotransformation
	Tryptophan metabolism
	Oxidation by Cytochrome P450
	Ovarian Infertility Genes
	Metabolism of steroid hormones and vitamin D
	FSH signaling pathway
	Integrated Breast Cancer Pathway
	Phase 1 - Functionalization of compounds
References
Ref 535139	A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80.
Ref 535139	A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. J Med Chem. 2001 Mar 1;44(5):672-80.

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