Drug Information

Drug General Information
Drug ID
D0B6PZ
Former ID
DNC004204
Drug Name
FORMESTANE
Drug Type
Small molecular drug
Indication Breast cancer [ICD9: 174, 175; ICD10:C50] Withdrawn from market [544725], [551871]
Structure
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2D MOL

3D MOL
Formula
C19H26O3
Canonical SMILES
CC12CCC(=O)C(=C1CCC3C2CCC4(C3CCC4=O)C)O
InChI
1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
InChIKey
OSVMTWJCGUFAOD-KZQROQTASA-N
CAS Number
CAS 566-48-3
PubChem Compound ID
11273
SuperDrug ATC ID
L02BG02
Target and Pathway
Target(s) Cytochrome P450 19 Target Info Inhibitor [530661]
BioCyc Pathway Superpathway of steroid hormone biosynthesis
Estradiol biosynthesis II
Estradiol biosynthesis I
KEGG Pathway Steroid hormone biosynthesis
Metabolic pathways
Ovarian steroidogenesis
NetPath Pathway FSH Signaling Pathway
PANTHER Pathway Androgen/estrogene/progesterone biosynthesis
PathWhiz Pathway Androgen and Estrogen Metabolism
Reactome Endogenous sterols
WikiPathways Metapathway biotransformation
Tryptophan metabolism
Oxidation by Cytochrome P450
Ovarian Infertility Genes
Metabolism of steroid hormones and vitamin D
FSH signaling pathway
Integrated Breast Cancer Pathway
Phase 1 - Functionalization of compounds
References
Ref 544725Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000733)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 530661J Nat Prod. 2010 Feb 26;73(2):284-98.The taiwaniaquinoids: a review.

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