Drug Information

Drug General Information
Drug ID
D0YU9L
Former ID
DNC009971
Drug Name
4-amino-1,2,5-oxadiazole-3-carboximidamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530194]
Structure
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2D MOL

3D MOL
Formula
C10H11N5O2
Canonical SMILES
C1=CC=C(C=C1)CNC(=C2C(=NON2)N)N=O
InChI
1S/C10H11N5O2/c11-9-8(14-17-15-9)10(13-16)12-6-7-4-2-1-3-5-7/h1-5,12,14H,6H2,(H2,11,15)/b10-8+
InChIKey
UATBBYALBWUQQE-CSKARUKUSA-N
PubChem Compound ID
5755869
Target and Pathway
Target(s) Indoleamine 2,3-dioxygenase Target Info Inhibitor [530194]
BioCyc Pathway Superpathway of tryptophan utilization
Tryptophan degradation
L-kynurenine degradation
Tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde
NAD de novo biosynthesis
KEGG Pathway Tryptophan metabolism
Metabolic pathways
African trypanosomiasis
NetPath Pathway TSLP Signaling Pathway
IL5 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PathWhiz Pathway Tryptophan Metabolism
Reactome Tryptophan catabolism
WikiPathways Tryptophan metabolism
Metabolism of amino acids and derivatives
References
Ref 530194J Med Chem. 2009 Dec 10;52(23):7364-7.Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.
Ref 530194J Med Chem. 2009 Dec 10;52(23):7364-7.Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model.

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