TTD | Drug: D0PB5Q

Drug General Information
Drug ID	D0PB5Q
Former ID	DNC001437
Drug Name	Thiorphan
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[540741]
Structure		Download 2D MOL 3D MOL
Formula	C12H15NO3S
InChI	InChI=1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)/t10-/m1/s1
InChIKey	LJJKNPQAGWVLDQ-SNVBAGLBSA-N
CAS Number	CAS 76721-89-6
PubChem Compound ID	4369380
PubChem Substance ID	855422, 7890783, 10934363, 11111898, 11112848, 35668595, 46393722, 46505664, 76472132, 99445097, 103241499, 103934393, 112947573, 128497589, 137127142, 160964889, 178101961, 179235826, 198966843, 226433357
Target and Pathway
Target(s)	Neutral endopeptidase	Target Info	Inhibitor	[535731]
KEGG Pathway	Renin-angiotensin system
	Hematopoietic cell lineage
	Protein digestion and absorption
	Alzheimer's disease
NetPath Pathway	EGFR1 Signaling Pathway
NetPath Pathway	TGF_beta_Receptor Signaling Pathway
Reactome	Metabolism of Angiotensinogen to Angiotensins
WikiPathways	Metabolism of Angiotensinogen to Angiotensins
	Primary Focal Segmental Glomerulosclerosis FSGS
	Alzheimers Disease
References
Ref 540741	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5278).
Ref 535731	Thiorphan enhances bradykinin-induced vascular relaxation in hypoxic/hyperkalaemic porcine coronary artery. J Pharm Pharmacol. 2003 Mar;55(3):339-45.

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Drug Information