| Drug General Information |
| Drug ID |
D01TDG
|
| Former ID |
DNC002495
|
| Drug Name |
S-Ethyl-N-Phenyl-Isothiourea
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C9H12N2S
|
| Canonical SMILES |
CCSC(=NC1=CC=CC=C1)N
|
| InChI |
1S/C9H12N2S/c1-2-12-9(10)11-8-6-4-3-5-7-8/h3-7H,2H2,1H3,(H2,10,11)
|
| InChIKey |
LAXNJIWNBHHMDO-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| PubChem Substance ID |
824001, 836790, 5911242, 6584790, 7890093, 15091628, 41494571, 46506739, 50917541, 57401843, 72000121, 103642151, 103954393, 104116463, 104574190, 108169238, 128462913, 132525872, 137131131, 160966802, 162262849, 162810699, 164841419, 225042489, 227604279
|
| Target and Pathway |
| Target(s) |
Nitric-oxide synthase, brain |
Target Info |
Inhibitor |
[1]
|
|---|
| Nitric-oxide synthase, endothelial |
Target Info |
Inhibitor |
[1]
|
|
BioCyc Pathway
|
Citrulline-nitric oxide cyclePWY-4983:Citrulline-nitric oxide cycle
|
|
KEGG Pathway
|
Arginine and proline metabolism
|
|
Metabolic pathways
|
|
Calcium signaling pathway
|
|
Phagosome
|
|
Circadian entrainment
|
|
Long-term depression
|
|
Salivary secretion
|
|
Alzheimer's disease
|
|
Amyotrophic lateral sclerosis (ALS)hsa00330:Arginine and proline metabolism
|
|
cGMP-PKG signaling pathway
|
|
HIF-1 signaling pathway
|
|
Sphingolipid signaling pathway
|
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PI3K-Akt signaling pathway
|
|
VEGF signaling pathway
|
|
Platelet activation
|
|
Estrogen signaling pathway
|
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Oxytocin signaling pathway
|
|
NetPath Pathway
|
EGFR1 Signaling PathwayNetPath_8:Wnt Signaling Pathway
|
|
PANTHER Pathway
|
CCKR signaling map STP00005:Angiogenesis
|
|
Endothelin signaling pathway
|
|
Interleukin signaling pathway
|
|
PI3 kinase pathway
|
|
VEGF signaling pathway
|
|
Pathway Interaction Database
|
Plasma membrane estrogen receptor signaling
|
|
Validated transcriptional targets of AP1 family members Fra1 and Fra2
|
|
Angiopoietin receptor Tie2-mediated signaling
|
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Thromboxane A2 receptor signaling
|
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SHP2 signaling
|
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VEGFR1 specific signals
|
|
Signaling events mediated by VEGFR1 and VEGFR2
|
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PAR1-mediated thrombin signaling events
|
|
PathWhiz Pathway
|
Arginine and Proline Metabolism
|
|
Reactome
|
ROS production in response to bacteria
|
|
Nitric oxide stimulates guanylate cyclaseR-HSA-1222556:ROS production in response to bacteria
|
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Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
|
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eNOS activation
|
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Nitric oxide stimulates guanylate cyclase
|
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VEGFR2 mediated vascular permeability
|
|
WikiPathways
|
Monoamine Transport
|
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Myometrial Relaxation and Contraction Pathways
|
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Amyotrophic lateral sclerosis (ALS)
|
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Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
|
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Spinal Cord Injury
|
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Alzheimers Disease
|
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Effects of Nitric Oxide
|
|
Serotonin Transporter ActivityWP554:ACE Inhibitor Pathway
|
|
EGF/EGFR Signaling Pathway
|
|
JAK/STAT
|
|
Corticotropin-releasing hormone
|
|
AGE/RAGE pathway
|
|
Endothelin Pathways
|
|
Leptin signaling pathway
|
|
Metabolism of nitric oxide
|
|
Angiogenesis
|
| References |
| REF 1 | The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. |
|---|
