Drug Information

Drug General Information
Drug ID
D0P5ZE
Former ID
DNC005313
Drug Name
Cyclohexyl-(2-phenoxy-9H-purin-6-yl)-amine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527647]
Structure
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2D MOL

3D MOL
Formula
C17H19N5O
Canonical SMILES
C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)OC4=CC=CC=C4
InChI
1S/C17H19N5O/c1-3-7-12(8-4-1)20-16-14-15(19-11-18-14)21-17(22-16)23-13-9-5-2-6-10-13/h2,5-6,9-12H,1,3-4,7-8H2,(H2,18,19,20,21,22)
InChIKey
OGCQBCHLFMBCCE-UHFFFAOYSA-N
PubChem Compound ID
11771279
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Inhibitor [527647]
Adenosine A2a receptor Target Info Inhibitor [527647]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-187024:NGF-independant TRKA activation
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
Monoamine Transport
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527647J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.
Ref 527647J Med Chem. 2005 Jul 28;48(15):4910-8."Reversine" and its 2-substituted adenine derivatives as potent and selective A3 adenosine receptor antagonists.

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