Drug Information

Drug General Information
Drug ID
D02PBS
Former ID
DNC005970
Drug Name
7-benzoyloxy-2-(morpholin-4-yl)-chromen-4-one
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527888]
Structure
Download
2D MOL

3D MOL
Formula
C20H17NO5
Canonical SMILES
C1COCCN1C2=CC(=O)C3=C(O2)C=C(C=C3)OC(=O)C4=CC=CC=C4
InChI
1S/C20H17NO5/c22-17-13-19(21-8-10-24-11-9-21)26-18-12-15(6-7-16(17)18)25-20(23)14-4-2-1-3-5-14/h1-7,12-13H,8-11H2
InChIKey
GIEJDWWZPMOULL-UHFFFAOYSA-N
PubChem Compound ID
11508573
Target and Pathway
Target(s) DNA-dependent protein kinase catalytic subunit Target Info Inhibitor [527888]
KEGG Pathway Non-homologous end-joining
Cell cycle
NetPath Pathway IL1 Signaling Pathway
Pathway Interaction Database DNA-PK pathway in nonhomologous end joining
Coregulation of Androgen receptor activity
Class I PI3K signaling events mediated by Akt
BARD1 signaling events
Reactome Nonhomologous End-Joining (NHEJ)
WikiPathways DNA Damage Response
Non-homologous end joining
FAS pathway and Stress induction of HSP regulation
Cytosolic sensors of pathogen-associated DNA
Retinoblastoma (RB) in Cancer
Prostate Cancer
Double-Strand Break Repair
Cell Cycle
miRNA Regulation of DNA Damage Response
References
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.
Ref 527888J Med Chem. 2005 Dec 1;48(24):7829-46.Discovery of potent chromen-4-one inhibitors of the DNA-dependent protein kinase (DNA-PK) using a small-molecule library approach.

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