Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D07HOB
|
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| Former ID |
DAP000647
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| Drug Name |
Irinotecan
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| Synonyms |
Biotecan; Camptosar; Irinotecanum; IRINOTECAN HYDROCHLORIDE Trihydrate; Irinotecan Hcl; Irinotecan hydrochloride; CP0; Biotecan (TN); Campto (TN); Camptosar (TN); Irinotecan (INN); Irinotecan [INN:BAN]; Irinotecanum [INN-Latin]; IRINOTECAN, CPT-11; Camptosar, Campto, CPT-11, Irinotecan; (+)-Irinotecan; (4S)-4,11-DIETHYL-4-HYDROXY-3,14-DIOXO-3,4,12,14-TETRAHYDRO-1H-PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLIN-9-YL 1,4'-BIPIPERIDINE-1'-CARBOXYLATE; (4S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-4,12-dihydro-1H-pyrano[3,4-f]quinolino[2,3-a]indolizin-9-yl 4-piperidylpiperidinecarboxylate; Irinotecan (TOPO1 inhibitor)
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Anticancer Agents
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| Company |
Pfizer Pharmaceuticals
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| Structure |
|
Download2D MOL |
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| Formula |
C33H38N4O6
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| InChI |
InChI=1S/C33H38N4O6/c1-3-22-23-16-21(43-32(40)36-14-10-20(11-15-36)35-12-6-5-7-13-35)8-9-27(23)34-29-24(22)18-37-28(29)17-26-25(30(37)38)19-42-31(39)33(26,41)4-2/h8-9,16-17,20,41H,3-7,10-15,18-19H2,1-2H3/t33-/m0/s1
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| InChIKey |
UWKQSNNFCGGAFS-XIFFEERXSA-N
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| CAS Number |
CAS 100286-90-6
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| PubChem Compound ID | |||||
| PubChem Substance ID |
645391, 6436484, 7886725, 7979640, 8187089, 11409441, 14764625, 14911520, 43118176, 46393294, 46505871, 47811029, 48427687, 49835834, 49894524, 50422254, 51090967, 53788707, 56312891, 56314523, 57288560, 57314141, 81092817, 85789488, 92711320, 96024776, 103169165, 104020044, 104253165, 104321776, 117623718, 118049657, 124757074, 124893595, 125163878, 126630981, 126650121, 126663759, 129430288, 134337937, 134338553, 135032920, 136342503, 137001856, 142371089, 143493285, 143493286, 144116083, 152034388, 152240238
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| SuperDrug ATC ID |
L01XX19
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| SuperDrug CAS ID |
cas=097682445
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| Drug Resistance Mutation (DRM) | |||||
| DRM | DRM Info | ||||
| Target and Pathway | |||||
| Target(s) | DNA topoisomerase I | Target Info | Modulator | [556264] | |
| WikiPathways | Integrated Pancreatic Cancer Pathway | ||||
| References | |||||
| Ref 535668 | New drugs for the treatment of cancer, 1990-2001. Isr Med Assoc J. 2002 Dec;4(12):1124-31. | ||||
| Ref 541905 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6823). | ||||
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