Drug Information

Drug General Information
Drug ID
D01AAI
Former ID
DIB021204
Drug Name
VUF5574
Synonyms
VUF 5574; VUF-5574
Drug Type
Small molecular drug
Indication Discovery agent Investigative [540244]
Structure
Download
2D MOL
Formula
C21H17N5O2
InChI
InChI=1S/C21H17N5O2/c1-28-18-11-5-4-10-17(18)24-21(27)26-20-15-8-2-3-9-16(15)23-19(25-20)14-7-6-12-22-13-14/h2-13H,1H3,(H2,23,24,25,26,27)
InChIKey
YRAFEJSZTVWUMD-UHFFFAOYSA-N
PubChem Compound ID
4046493
PubChem Substance ID
5950368, 9446063, 11111956, 14779586, 17405801, 24278772, 26753673, 35306473, 47425390, 50107192, 50107193, 50107194, 50159373, 53778353, 57356688, 85231283, 89077934, 92303145, 103269001, 103987390, 105296783, 112596066, 121364787, 124750354, 124881800, 124881801, 124881802, 129835621, 134964208, 135698538, 162250190, 163123911, 165358675, 178100321, 204356811, 227197517, 241182360, 252216598
Target and Pathway
Target(s) Adenosine A3 receptor Target Info Antagonist [525784]
Adenosine A1 receptor Target Info Antagonist [534717]
Adenosine A2b receptor Target Info Antagonist [534717]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addictionhsa04015:Rap1 signaling pathway
Calcium signaling pathway
Vascular smooth muscle contraction
Alcoholism
NetPath Pathway TCR Signaling Pathway
RANKL Signaling PathwayNetPath_7:TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Pathway Interaction Database C-MYB transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
Reactome Adenosine P1 receptors
G alpha (i) signalling eventsR-HSA-417973:Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCRs, OtherWP80:Nucleotide GPCRs
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCR downstream signaling
References
Ref 540244(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3280).
Ref 525784J Med Chem. 2000 Jun 1;43(11):2227-38.Isoquinoline and quinazoline urea analogues as antagonists for the human adenosine A(3) receptor.
Ref 534717J Med Chem. 1998 Oct 8;41(21):3987-93.A novel class of adenosine A3 receptor ligands. 1. 3-(2-Pyridinyl)isoquinoline derivatives.

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