Drug General Information
Drug ID	D0C1NP
Former ID	DIB019520
Drug Name	compound 4g
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[531910]
Structure		Download 2D MOL
Formula	C13H13NO5
InChI	InChI=1S/C13H13NO5/c1-13(2)11(16)14(12(17)19-13)10(15)8-4-6-9(18-3)7-5-8/h4-7H,1-3H3
InChIKey	ZYRNCIWULACSEK-UHFFFAOYSA-N
PubChem Compound ID	66561876
PubChem Substance ID	152192579, 160673055, 160863194, 252166826
Target and Pathway
Target(s)	Leukocyte proteinase-3	Target Info	Inhibitor	[531910]
	Cathepsin G	Target Info	Inhibitor	[531910]
	Leukocyte elastase	Target Info	Inhibitor	[531910]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Lysosome
	Renin-angiotensin system
	Amoebiasis
	Systemic lupus erythematosushsa05202:Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	C-MYB transcription factor networkupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signalingupa_upar_pathway:Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Common Pathway of Fibrin Clot FormationR-HSA-1474228:Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
	Metabolism of Angiotensinogen to Angiotensins
	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-1442490:Collagen degradation
	Degradation of the extracellular matrix
WikiPathways	ACE Inhibitor Pathway
	Regulation of Insulin-like Growth Factor (IGF) Transport and Uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)WP2840:Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 531910	N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7.
Ref 531910	N-Acyl and N-sulfonyloxazolidine-2,4-diones are pseudo-irreversible inhibitors of serine proteases. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3993-7.

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