Drug Information

Drug General Information
Drug ID
D0N5IE
Former ID
DNC011507
Drug Name
1-Phenyl-3-(4-pyridin-2-yl-thiazol-2-yl)-urea
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526011]
Structure
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2D MOL

3D MOL
Formula
C15H12N4OS
Canonical SMILES
C1=CC=C(C=C1)NC(=O)NC2=NC(=CS2)C3=CC=CC=N3
InChI
1S/C15H12N4OS/c20-14(17-11-6-2-1-3-7-11)19-15-18-13(10-21-15)12-8-4-5-9-16-12/h1-10H,(H2,17,18,19,20)
InChIKey
SDGJJDKFCDDMKK-UHFFFAOYSA-N
PubChem Compound ID
10590030
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Inhibitor [526011]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 526011J Med Chem. 2001 Mar 1;44(5):749-62.Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.
Ref 526011J Med Chem. 2001 Mar 1;44(5):749-62.Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.

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