Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D02RIH
|
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| Former ID |
DIB018053
|
||||
| Drug Name |
(-)-(S)-BayK8644
|
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [540659] | ||
| Structure |
|
Download2D MOL |
|||
| Formula |
C16H15F3N2O4
|
||||
| InChI |
InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1
|
||||
| InChIKey |
ZFLWDHHVRRZMEI-ZDUSSCGKSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Cav1.4 | Target Info | Activator | [543868] | |
| Cav1.1 | Target Info | Activator | [543865] | ||
| Voltage-dependent L-type calcium channel alpha-1D subunit | Target Info | Activator | [543867] | ||
| Voltage-dependent L-type calcium channel subunit alpha-1C | Target Info | Activator | [543866] | ||
| KEGG Pathway | MAPK signaling pathway | ||||
| Calcium signaling pathway | |||||
| cGMP-PKG signaling pathway | |||||
| cAMP signaling pathway | |||||
| Cardiac muscle contraction | |||||
| Adrenergic signaling in cardiomyocytes | |||||
| Vascular smooth muscle contraction | |||||
| Circadian entrainment | |||||
| Retrograde endocannabinoid signaling | |||||
| Glutamatergic synapse | |||||
| Cholinergic synapse | |||||
| Serotonergic synapse | |||||
| GABAergic synapse | |||||
| Dopaminergic synapse | |||||
| Insulin secretion | |||||
| GnRH signaling pathway | |||||
| Oxytocin signaling pathway | |||||
| Type II diabetes mellitus | |||||
| Carbohydrate digestion and absorption | |||||
| Alzheimer's disease | |||||
| Amphetamine addiction | |||||
| Hypertrophic cardiomyopathy (HCM) | |||||
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | |||||
| Dilated cardiomyopathyhsa04010:MAPK signaling pathway | |||||
| Long-term potentiation | |||||
| Dilated cardiomyopathy | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| PANTHER Pathway | Alzheimer disease-amyloid secretase pathway | ||||
| Nicotinic acetylcholine receptor signaling pathway | |||||
| 5HT2 type receptor mediated signaling pathway | |||||
| Beta1 adrenergic receptor signaling pathway | |||||
| Beta2 adrenergic receptor signaling pathway | |||||
| Oxytocin receptor mediated signaling pathwayP00003:Alzheimer disease-amyloid secretase pathway | |||||
| Oxytocin receptor mediated signaling pathway | |||||
| Nicotine pharmacodynamics pathway | |||||
| PathWhiz Pathway | Muscle/Heart Contraction | ||||
| WikiPathways | Calcium Regulation in the Cardiac Cell | ||||
| Arrhythmogenic Right Ventricular Cardiomyopathy | |||||
| Alzheimers Disease | |||||
| NCAM signaling for neurite out-growth | |||||
| Integration of energy metabolismWP536:Calcium Regulation in the Cardiac Cell | |||||
| Integration of energy metabolism | |||||
| Nicotine Activity on Chromaffin Cells | |||||
| References | |||||
| Ref 543865 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 528). | ||||
| Ref 543866 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 529). | ||||
| Ref 543867 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 530). | ||||
| Ref 543868 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 531). | ||||
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