Drug Information
Drug General Information | |||||
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Drug ID |
D0S4MN
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Former ID |
DIB021155
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Drug Name |
veratridine
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Synonyms |
veratrine; 3-veratroylveracevine
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [539696] | ||
Structure |
Download2D MOL |
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Formula |
C36H51NO11
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InChI |
InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
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InChIKey |
FVECELJHCSPHKY-YFUMOZOISA-N
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PubChem Compound ID | |||||
PubChem Substance ID |
8137895, 11445999, 43526946, 46530453, 48393489, 50062968, 50111382, 53788722, 78684425, 85788256, 85856318, 92309931, 99300845, 103072066, 103081921, 104045143, 104311613, 134972303, 135652724, 136046139, 137005967, 175607798, 184582578, 194154853, 198983944, 226433616, 241376167, 249583246, 252156874, 252402715, 252455655
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Target and Pathway | |||||
Target(s) | mRNA of SCN1A | Target Info | Activator | [543880] | |
Voltage-gated sodium channel subunit alpha Nav1.3 | Target Info | Activator | [543881] | ||
Sodium channel protein type 2 subunit alpha | Target Info | Activator | [533513] | ||
SCN8A sodium channel subunit | Target Info | Activator | [543883] | ||
Sodium channel protein type 5 subunit alpha | Target Info | Activator | [531463] | ||
Sodium channel protein type 4 subunit alpha | Target Info | Activator | [534563] | ||
Voltage-gated sodium channel subunit alpha Nav1.8 | Target Info | Activator | [529119] | ||
Voltage-gated sodium channel subunit alpha Nav1.7 | Target Info | Activator | [543884] | ||
PathWhiz Pathway | Muscle/Heart Contraction | ||||
References | |||||
Ref 529119 | A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons. Pflugers Arch. 2008 Feb;455(5):929-38. Epub 2007 Oct 26. | ||||
Ref 531463 | Sodium channel comodification with full activator reveals veratridine reaction dynamics. Mol Pharmacol. 1990 Feb;37(2):144-8. | ||||
Ref 533513 | Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7. | ||||
Ref 534563 | Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8. | ||||
Ref 543880 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578). | ||||
Ref 543881 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580). | ||||
Ref 543883 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583). | ||||
Ref 543884 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584). |
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