Drug General Information
Drug ID
D0S4MN
Former ID
DIB021155
Drug Name
veratridine
Synonyms
veratrine; 3-veratroylveracevine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539696]
Structure
Download
2D MOL
Formula
C36H51NO11
InChI
InChI=1S/C36H51NO11/c1-19-6-11-26-31(3,40)35(43)25(17-37(26)16-19)33(42)18-34-24(32(33,41)15-27(35)38)10-9-23-30(34,2)13-12-28(36(23,44)48-34)47-29(39)20-7-8-21(45-4)22(14-20)46-5/h7-8,14,19,23-28,38,40-44H,6,9-13,15-18H2,1-5H3/t19-,23-,24-,25-,26-,27-,28-,30-,31+,32+,33+,34+,35-,36-/m0/s1
InChIKey
FVECELJHCSPHKY-YFUMOZOISA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) mRNA of SCN1A Target Info Activator [543880]
Voltage-gated sodium channel subunit alpha Nav1.3 Target Info Activator [543881]
Sodium channel protein type 2 subunit alpha Target Info Activator [533513]
SCN8A sodium channel subunit Target Info Activator [543883]
Sodium channel protein type 5 subunit alpha Target Info Activator [531463]
Sodium channel protein type 4 subunit alpha Target Info Activator [534563]
Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Activator [529119]
Voltage-gated sodium channel subunit alpha Nav1.7 Target Info Activator [543884]
KEGG Pathway Dopaminergic synapsehsa04261:Adrenergic signaling in cardiomyocytes
PathWhiz Pathway Muscle/Heart Contraction
Reactome Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and AnkyrinsR-HSA-445095:Interaction between L1 and Ankyrins
WikiPathways SIDS Susceptibility Pathways
Cardiac Progenitor Differentiation
References
Ref 539696(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2626).
Ref 529119A comparison of the effects of veratridine on tetrodotoxin-sensitive and tetrodotoxin-resistant sodium channels in isolated rat dorsal root ganglion neurons. Pflugers Arch. 2008 Feb;455(5):929-38. Epub 2007 Oct 26.
Ref 531463Sodium channel comodification with full activator reveals veratridine reaction dynamics. Mol Pharmacol. 1990 Feb;37(2):144-8.
Ref 533513Binding of batrachotoxinin A 20-alpha-benzoate to a receptor site associated with sodium channels in synaptic nerve ending particles. J Biol Chem. 1981 Sep 10;256(17):8922-7.
Ref 534563Point mutations in segment I-S6 render voltage-gated Na+ channels resistant to batrachotoxin. Proc Natl Acad Sci U S A. 1998 Mar 3;95(5):2653-8.
Ref 543880(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 578).
Ref 543881(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 580).
Ref 543883(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 583).
Ref 543884(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 584).

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