Drug Information

Drug General Information
Drug ID
D06IXI
Former ID
DIB019028
Drug Name
BrP-LPA
Synonyms
alpha-bromomethylene phosphonate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [530196]
Structure
Download
2D MOL
Formula
C20H40BrO6P
InChI
InChI=1S/C20H40BrO6P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-20(23)27-17-18(22)16-19(21)28(24,25)26/h18-19,22H,2-17H2,1H3,(H2,24,25,26)/t18-,19?/m0/s1
InChIKey
HLVKVWDSLLFMSX-OYKVQYDMSA-N
PubChem Compound ID
16725999
PubChem Substance ID
46135650, 178103564, 229106741, 245707135
Target and Pathway
Target(s) Lysophosphatidic acid receptor Edg-2 Target Info Antagonist [530196]
LPA2 receptor Target Info Antagonist [530196]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
PI3K-Akt signaling pathway
Gap junction
Pathways in cancer
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Pathway Interaction Database LPA receptor mediated events
Reactome G alpha (q) signalling events
G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Myometrial Relaxation and Contraction Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 530196Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9.
Ref 530196Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 2009 Jul 1;69(13):5441-9.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.