Drug Information
Drug General Information | |||||
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Drug ID |
D0W5IN
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Former ID |
DNC012045
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Drug Name |
(2-Methyl-indol-1-yl)-propyl-pyridin-4-yl-amine
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Drug Type |
Small molecular drug
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Indication | Discovery agent | Investigative | [1] | ||
Structure |
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Download2D MOL |
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Formula |
C17H19N3
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Canonical SMILES |
CCCN(C1=CC=NC=C1)N2C(=CC3=CC=CC=C32)C
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InChI |
1S/C17H19N3/c1-3-12-19(16-8-10-18-11-9-16)20-14(2)13-15-6-4-5-7-17(15)20/h4-11,13H,3,12H2,1-2H3
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InChIKey |
JCEBKNUYKMFQGZ-UHFFFAOYSA-N
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | Alpha-2C adrenergic receptor | Target Info | Inhibitor | [1] | |
Alpha-2B adrenergic receptor | Target Info | Inhibitor | [1] | ||
Alpha-2A adrenergic receptor | Target Info | Inhibitor | [1] | ||
KEGG Pathway | cGMP-PKG signaling pathway | ||||
Neuroactive ligand-receptor interactionhsa04022:cGMP-PKG signaling pathway | |||||
Neuroactive ligand-receptor interaction | |||||
PANTHER Pathway | Alpha adrenergic receptor signaling pathway | ||||
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP00002:Alpha adrenergic receptor signaling pathway | |||||
Reactome | Adrenoceptors | ||||
Adrenaline signalling through Alpha-2 adrenergic receptor | |||||
Adrenaline,noradrenaline inhibits insulin secretion | |||||
G alpha (i) signalling events | |||||
G alpha (z) signalling events | |||||
Surfactant metabolismR-HSA-390696:Adrenoceptors | |||||
G alpha (z) signalling eventsR-HSA-390696:Adrenoceptors | |||||
Surfactant metabolism | |||||
WikiPathways | Monoamine GPCRs | ||||
GPCRs, Class A Rhodopsin-like | |||||
Platelet Aggregation (Plug Formation) | |||||
Integration of energy metabolism | |||||
GPCR ligand binding | |||||
GPCR downstream signalingWP58:Monoamine GPCRs | |||||
GPCR downstream signaling | |||||
References | |||||
REF 1 | J Med Chem. 1996 Jan 19;39(2):570-81.Synthesis and structure-activity relationships of N-propyl-N-(4-pyridinyl)-1H-indol-1-amine (besipirdine) and related analogs as potential therapeutic agents for Alzheimer's disease. | ||||
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